{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:41:41Z","timestamp":1777909301384,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>\n                    Metabolic syndrome (MetS) is a combination of risk factors that include insulin resistance, obesity, dyslipidemia, and hypertension. The consumption of high-fructose diets contributes to the development of MetS.\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -sitosterol a naturally occurring phytosterol possesses antiobesogenic and antidiabetic effects. This study evaluated the potential protective effect of\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -sitosterol against the development of metabolic dysfunction in growing female rats fed a high-fructose diet, mimicking children fed obesogenic diets. Thirty-five 21-day-old female Sprague Dawley rat pups were randomly allocated to and administered the following treatments: group 1\u2014standard rat chow (SRC) + plain drinking water (PW)\u2009+\u2009plain gelatine cube (PC); group 2\u2014SRC\u2009+\u200920% w\/w fructose solution (FS) as drinking fluid\u2009+\u2009PC; group 3\u2014SRC\u2009+\u2009FS\u2009+\u2009100\u2009mg\/kg fenofibrate in gelatine cubes; group 4\u2014SRC\u2009+\u2009FS\u2009+\u200920\u2009mg\/kg\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -sitosterol gelatine cube (Bst); and group 5\u2014SRC\u2009+\u2009PW\u2009+\u2009Bst. Following 12 weeks of feeding, the rats were fasted overnight, weighed, and then euthanized. Plasma cholesterol, insulin, glucose, triglyceride, and adiponectin concentrations were determined. Visceral fat was dissected out and weighed. The high-fructose diet increased (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05) visceral adiposity and plasma triglyceride concentration but decreased (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05) plasma adiponectin concentration.\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -sitosterol prevented the high-fructose diet-induced visceral obesity, hypertriglyceridemia, and hypoadiponectinemia.\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -sitosterol alone increased plasma adiponectin concentration and reduced plasma insulin concentration and homeostatic model assessment index. In conclusion,\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -sitosterol could be potentially used to prevent high-fructose diet-induced metabolic dysfunction.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2019.0120","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T10:14:47Z","timestamp":1568369687000},"page":"367-374","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["<i>\u03b2<\/i>\n                    -Sitosterol Shows Potential to Protect Against the Development of High-Fructose Diet-Induced Metabolic Dysfunction in Female Rats"],"prefix":"10.1177","volume":"23","author":[{"given":"Nontobeko M.","family":"Gumede","sequence":"first","affiliation":[{"name":"School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Busisani W.","family":"Lembede","sequence":"additional","affiliation":[{"name":"School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Brooksbank","sequence":"additional","affiliation":[{"name":"School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennedy H.","family":"Erlwanger","sequence":"additional","affiliation":[{"name":"School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliton","family":"Chivandi","sequence":"additional","affiliation":[{"name":"School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"e_1_3_4_2_2","volume-title":"Global Report Status on Noncommunicable Diseases 2014","author":"World Health Organisation","year":"2014","unstructured":"World Health Organisation: Global Report Status on Noncommunicable Diseases 2014. 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