{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:41:42Z","timestamp":1777909302621,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    In Central and South American traditional medicine, people use\n                    <jats:italic toggle=\"yes\">Cecropia obtusifolia<\/jats:italic>\n                    Bertol (Cecropiaceae) for the treatment of diabetes mellitus. However, its hypoglycemic action mechanism at pancreatic and liver level has been poorly explored. The present research aimed to establish the influence of the aqueous extract of\n                    <jats:italic toggle=\"yes\">C. obtusifolia<\/jats:italic>\n                    , standardized in its content of chlorogenic acid, on insulin secretion in RINm5F cells and over the liver carbohydrates and lipids metabolism, and to determine concomitantly its hepatoprotective effect on mice with streptozotocin-induced diabetes. In RINm5F cells, concentrations 5, 50, 100, and 200\u2009\n                    <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                    g\/mL of aqueous extract of\n                    <jats:italic toggle=\"yes\">C. obtusifolia<\/jats:italic>\n                    were used to determine [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    and insulin secretion. In an acute study, the extract was administered at doses of 500\u2009mg\/kg. In another test (subacute), the extract was daily administrated to diabetic mice (200\u2009mg\/kg\/day) for 30 days. Blood glucose levels and other biochemical parameters were determined, and a liver histological analysis was performed. In RINm5F cells,\n                    <jats:italic toggle=\"yes\">C. obtusifolia<\/jats:italic>\n                    increased [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    and insulin secretion, whereas in diabetic mice exhibited acute and subacute hypoglycemic effects. Daily administration of\n                    <jats:italic toggle=\"yes\">C. obtusifolia<\/jats:italic>\n                    to diabetic mice also increased liver glycogen storage and glycogen synthase levels, without apparent changes in gluconeogenesis. Besides, it increased peroxisome proliferator-activated receptor-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">PPAR-\u03b1<\/jats:italic>\n                    ) and long-chain-fatty-acid-CoA ligase 1 (\n                    <jats:italic toggle=\"yes\">ACSL-1<\/jats:italic>\n                    ) expression and reduced triglycerides, transaminases (alanine aminotransferase and aspartate aminotransferase), and collagen fibers, modifying anti-inflammatory (adiponectin and interleukin-10) and inflammatory (tumor necrosis factor-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    ) cytokines in serum. Therefore, the hypoglycemic effect of\n                    <jats:italic toggle=\"yes\">C. obtusifolia<\/jats:italic>\n                    implicates a dual action, promoting insulin secretion, liver glycogen accumulation, and hepatoprotection by decreasing collagen fibers and inflammatory markers, whereas it improves lipid metabolism, due in part to PPAR-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/jmf.2019.0126","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T14:58:36Z","timestamp":1573657116000},"page":"783-792","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Mechanism of the Hypoglycemic Activity and Hepatoprotective Effect of the Aqueous Extract of\n                    <i>Cecropia obtusifolia<\/i>\n                    Bertol"],"prefix":"10.1177","volume":"23","author":[{"given":"Mar\u00eda de los \u00c1ngeles","family":"Fortis-Barrera","sequence":"first","affiliation":[{"name":"Division of Health and Biological Sciences, Laboratory of Pharmacology, Department of Health Sciences, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Alarc\u00f3n-Aguilar","sequence":"additional","affiliation":[{"name":"Division of Health and Biological Sciences, Laboratory of Pharmacology, Department of Health Sciences, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araceli","family":"Becerril-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Division of Health and Biological Sciences, Laboratory of Pharmacology, Department of Health Sciences, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis Eduardo","family":"Flores-S\u00e1enz","sequence":"additional","affiliation":[{"name":"Division of Health and Biological Sciences, Laboratory of Pharmacology, Department of Health Sciences, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio Cesar","family":"Almanza-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Division of Health and Biological Sciences, Laboratory of Pharmacology, Department of Health Sciences, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Garc\u00eda-Lorenzana","sequence":"additional","affiliation":[{"name":"Division of Health and Biological Sciences, Laboratory of Tissue Neurobiology, Department of Reproduction Biology, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Carlos","family":"Lazzarini-Lechuga","sequence":"additional","affiliation":[{"name":"Division of Health and Biological Sciences, Laboratory of Confocal Microscopy, Department of Reproduction Biology, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n","family":"Rom\u00e1n-Ramos","sequence":"additional","affiliation":[{"name":"Division of Health and Biological Sciences, Laboratory of Pharmacology, Department of Health Sciences, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Blancas-Flores","sequence":"additional","affiliation":[{"name":"Division of Health and Biological Sciences, Laboratory of Pharmacology, Department of Health Sciences, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"913","article-title":"Chemical and pharmacological aspects of the genus Cecropia","volume":"6","author":"Costa GM","year":"2011","unstructured":"Costa GM, , Schenkel EP, , Reginatto FH: Chemical and pharmacological aspects of the genus Cecropia. 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