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Various dietary approaches are proposed for the obesity treatment and its associated metabolic disorders. Good taste, antioxidant functions, and vitamins have been attributed to virgin coconut oil (VCO). However, VCO contains a large amount of saturated fatty acids, and the consumption of this fat is associated with a number of secondary diseases. We evaluate the effects of VCO supplementation on biochemical, inflammatory, and oxidative stress parameters in rats fed with high-fat diet (HFD). After feeding with HFD for 12 weeks, the animals were supplemented with VCO for 30 days. HFD+VCO group increased in diet intake, weight gain, low-density lipoprotein cholesterol level, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. These findings were accompanied by increased in hepatic lipid profile and fat deposition in the liver. Adipocyte hypertrophy was observed in the HFD+VCO group, which was associated with elevated expression of tumor necrosis factor alpha (TNF-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    ) in adipose tissue. These results revealed that VCO associated with HFD induced important metabolic alterations, adipose inflammation, and hepatic lipid accumulation in rats.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2019.0172","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T15:18:44Z","timestamp":1575472724000},"page":"689-698","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Virgin Coconut Oil Associated with High-Fat Diet Induces Metabolic Dysfunctions, Adipose Inflammation, and Hepatic Lipid Accumulation"],"prefix":"10.1177","volume":"23","author":[{"given":"Deise Jaqueline","family":"Str\u00f6her","sequence":"first","affiliation":[{"name":"Graduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micaela Federizzi","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Course of Pharmacy, Federal University of Pampa, Uruguaiana, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Martinez-Oliveira","sequence":"additional","affiliation":[{"name":"Graduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Cocco","family":"Pilar","sequence":"additional","affiliation":[{"name":"Graduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia Denise Pavanelo","family":"Cattelan","sequence":"additional","affiliation":[{"name":"Graduate Program of Pharmaceutical Sciences, Federal University of Pampa, Uruguaiana, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliseu","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyne","family":"Bertolin","sequence":"additional","affiliation":[{"name":"Biotechnology and Animal Reproduction Laboratory, Federal University of Santa Maria, Santa Maria, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Bayard Dias","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Graduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Brazil."},{"name":"Biotechnology and Animal Reproduction Laboratory, Federal University of Santa Maria, Santa Maria, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline da Costa Escobar","family":"Piccoli","sequence":"additional","affiliation":[{"name":"Graduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanusa","family":"Manfredini","sequence":"additional","affiliation":[{"name":"Graduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Brazil."},{"name":"Graduate Program of Physiological Sciences, Federal University of Pampa, Uruguaiana, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2013.16.3.143"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132672"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2004.11.001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0889"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2012.36.1.13"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.12.013"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3fo60085h"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2009.06.003"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/09637480802549127"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.8650"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13668-018-0230-5"},{"key":"e_1_3_3_13_2","first-page":"2103","article-title":"Differences in chemical components and antioxidant-related substances in virgin coconut oil from coconut hybrids and their parents","volume":"20","author":"Arlee R","year":"2013","unstructured":"Arlee R, , Suanphairoch S, , Pakdeechanuan P: Differences in chemical components and antioxidant-related substances in virgin coconut oil from coconut hybrids and their parents. 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