{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:20:18Z","timestamp":1788542418723,"version":"build-2803163510"},"reference-count":54,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Hordei Fructus Germinatus<\/jats:italic>\n                    (HFG) has been used as a traditional medicine to treat functional dyspepsia (FD) in China. Stir fried HFG (F-HFG) containing Maillard reaction products (MRPs) is used more widely than the raw HFG (R-HFG). However, the exact mechanisms in its functionality remain unclear. This article investigated the effect of R-HFG, F-HFG, and MRPs on brain-gut peptides, gut microbiota, and digestive enzymes using an FD animal mode. After administration of R-HFG, F-HFG, and MRPs, higher mRNA expression level of gastrin\n                    <jats:italic toggle=\"yes\">(GAS)<\/jats:italic>\n                    and lower mRNA expression level of vasoactive intestinal peptide\n                    <jats:italic toggle=\"yes\">(VIP)<\/jats:italic>\n                    were exhibited in F-HFG and MRPs rats than R-HFG rats (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Furthermore, compared with the R-HFG group, the contents of motilin (MTL) and GAS showed an upward tendency, whereas the contents of VIP and chokcystokinin (CCK) showed a downward tendency in the F-HFG group. In addition, bacterial communities in the control, F-HFG, and MRPs groups clustered closely to one another, and bacterial communities in the model and recovery groups clustered together, whereas the bacterial communities in the R-HFG group were clustered into a category. Moreover, there were no apparent differences in brain-gut peptides and gut microbiota between the F-HFG and MRPs groups. However, after the oral administration of R-HFG, F-HFG, and MRPs, the level of digestive enzyme did not show a significant change as compared with the recovery group. These results indicated that the stronger effect of F-HFG could be attributed to the MRPs produced during stir frying, and MRPs possessed the effect of regulating brain-gut peptides and gut microbiota.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2019.4430","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T14:53:32Z","timestamp":1579791212000},"page":"420-431","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Maillard Reaction Products of Stir Fried\n                    <i>Hordei Fructus Germinatus<\/i>\n                    Are Important for Its Efficacy in Treating Functional Dyspepsia"],"prefix":"10.1177","volume":"23","author":[{"given":"Lu","family":"Wu","sequence":"first","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huasheng","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X05002801"},{"key":"e_1_3_3_3_2","volume-title":"Pharmacopoeia of the People's Republic of China","author":"Chinese Pharmacopoeia Commission","year":"2015","unstructured":"Chinese Pharmacopoeia Commission: Pharmacopoeia of the People's Republic of China. 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