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Although thrombolytic therapy is routinely adopted in cases of ischemic stroke, various alternative natural neuroprotectants are also used as effective adjuvant therapies to recover neurofunction following ischemic stroke. Raffinee, a natural fermented product with strong antioxidant and neuroprotective activities, has antiatherogenic effects in animals and has exhibited neuroprotective effects in a clinical trial by recovering motor and sensory function following spinal cord lesion. This study reveals the advantageous effects of Raffinee on PC12 cells by decreasing hypoxia-induced apoptosis in mice with permanent middle cerebral artery occlusion (pMCAO) by increasing the levels of neurotrophic factors such as S100\u03b2, reducing serum inflammatory factors such as matrix metalloproteinases (MMP)-9\/MMP-2 ratio, tumor necrosis factor-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    , and interleukin (IL)-6 level, and increasing IL-10 levels. Significantly reduced brain infarct volume along with a favorable survival ratio was observed for pMCAO mice that received Raffinee, suggesting a neuroprotective potential of Raffinee in cases of acute ischemic stroke by suppressing apoptosis.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2019.4438","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T11:09:26Z","timestamp":1569236966000},"page":"1226-1234","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Beneficial Effects of Raffinee in Permanent Occulted Stroke Mice"],"prefix":"10.1177","volume":"22","author":[{"given":"Chun-Ching","family":"Chiu","sequence":"first","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan."},{"name":"Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan."},{"name":"Department of Medical Intensive Care Unit, Changhua Christian Hospital, Changhua, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jer-Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Ziel Enterprise Co., Ltd., Kaohsiung, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai-Ching","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan."},{"name":"Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan."},{"name":"Immunology Research Center, Chung Shan Medical University, Taichung, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bor-Show","family":"Tzang","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan."},{"name":"Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan."},{"name":"Immunology Research Center, Chung Shan Medical University, Taichung, Taiwan."},{"name":"Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"The World Health Report 2018","author":"WHO","year":"2018","unstructured":"WHO: The World Health Report 2018. 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