{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:42:07Z","timestamp":1777909327342,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    It is well known that nonalcoholic fatty liver disease (NAFLD) is a common disease worldwide because of unhealthy changes in dietary habits. In this study, we determined the effects of\n                    <jats:italic toggle=\"yes\">Tenebrio molitor<\/jats:italic>\n                    Linnaeus, 1758 extract (TML) and\n                    <jats:italic toggle=\"yes\">Allomyrina dichotoma<\/jats:italic>\n                    Linnaeus, 1771 larvae extract (ADL) in cellular and animal models.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    , TML and ADL treatments did not cause cytotoxicity, but attenuated the accumulation of lipid in HepG2 cells induced by free fatty acids.\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    , mice were orally treated with TML and ADL for 10 weeks during high-fat diet feeding. TML and ADL administration significantly reduced the weight of body, liver tissue, and adipose tissue. Serum lipid profiles, hepatic functional parameters, and glucose levels were ameliorated by TML and ADL. Moreover, TML and ADL suppressed increased lipogenesis and inflammation-related makers, and improved antioxidant enzyme activity. In liver tissue, the decreased lipid accumulation by administration of TML and ADL was observed using Oil Red O and Hematoxylin and Eosin staining. Therefore, we suggest that TML and ADL may be having a therapeutic potential and is used to develop a therapeutic agent for NAFLD.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2019.4536","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T02:17:23Z","timestamp":1588904243000},"page":"760-771","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Beneficial Effects of Insect Extracts on Nonalcoholic Fatty Liver Disease"],"prefix":"10.1177","volume":"23","author":[{"given":"Joo Young","family":"Lee","sequence":"first","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-Rang","family":"Im","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Shuk","family":"Shim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kon-Young","family":"Ji","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea."},{"name":"University of Science and Technology (UST), Korean Medicine Life Science, Daejeon Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungwook","family":"Chae","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea."},{"name":"University of Science and Technology (UST), Korean Medicine Life Science, Daejeon Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141121240"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep44819"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.1995.10.6.414"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.151977"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07165.x"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22603"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0498-7"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.274"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01083.x"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.08699.x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.9365"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33666"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/79697"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13505"},{"key":"e_1_3_4_16_2","first-page":"1329","article-title":"National cholesterol education program: Second report of the expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel II)","volume":"89","author":"Grundy SM","year":"1994","unstructured":"Grundy SM: National cholesterol education program: Second report of the expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel II). 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