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In this randomized, double-blind, placebo-controlled trial, 78 Korean participants were randomized to either an RDSW group that drank RDSW for 8 weeks or a placebo group. Clinical laboratory information was collected from all subjects at 0, 4, and 8 weeks. Both groups showed a significant reduction in total cholesterol (TC), whereas only the RDSW group demonstrated a significant decrease in low-density lipoprotein cholesterol (LDL-c) during the study. Stratified analysis of both groups revealed a significant reduction of TC in the moderately high TC subgroup. However, only the RDSW exhibited a significant decline of LDL-c in the high LDL-c subgroup. In addition, lipoprotein(a) decreased significantly in the RDSW group, but not in the placebo. RDSW did not affect other lipid profiles, including high-density lipoprotein cholesterol (HDL-c), triglyceride, free fatty acid, apolipoproteins, and other markers including inflammation marker, hematological parameters, blood and urine chemistry, and vital signs. RDSW improved lipid profiles by decreasing TC and LDL-c while maintaining HDL-c levels in people with hypercholesterolemia.<\/jats:p>","DOI":"10.1089\/jmf.2019.4658","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T22:27:43Z","timestamp":1591828063000},"page":"886-894","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Refined Deep Seawater Improves Serum Lipid Profile in Hypercholesterolemia: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial"],"prefix":"10.1177","volume":"23","author":[{"given":"Min-Jee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, Goyang, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Yeon","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Medicine, Dongguk University, 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