{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:54:46Z","timestamp":1781560486104,"version":"3.54.5"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2021,3]]},"abstract":"\n Cenostigma macrophyllum<\/jats:italic>\n Tul. var.\n acuminata<\/jats:italic>\n Teles Freire (Leguminosae\u2013Caesalpinioideae) is a medicinal plant traditionally used for treatment of gastric ulcer. This study evaluated the ulcer-healing activity of the hydroalcoholic fraction of\n C. macrophyllum<\/jats:italic>\n Tul. var.\n acuminata<\/jats:italic>\n Teles Freire leaves (\n Cm<\/jats:italic>\n -FHA) and the tea of the leaves of\n C. macrophyllum<\/jats:italic>\n (\n Cm<\/jats:italic>\n -tea), as well as the possible action of\n Cm<\/jats:italic>\n -FHA, through\n in vitro<\/jats:italic>\n models. Leaves of\n C. macrophyllum<\/jats:italic>\n were dried and powdered to obtain the\n Cm<\/jats:italic>\n -FHA. Subsequently, the\n Cm<\/jats:italic>\n -FHA was characterized phytochemically and biologically. Besides,\n Cm<\/jats:italic>\n -tea was prepared. The gastric healing effects of\n Cm<\/jats:italic>\n -tea and\n Cm<\/jats:italic>\n -FHA were analyzed using the model of acetic acid-induced gastric ulcer in rats. The human gastric adenocarcinoma (AGS) cell line was employed as an\n in vitro<\/jats:italic>\n model.\n Cm<\/jats:italic>\n -tea promoted a protective effect against gastric ulcers induced by absolute ethanol.\n Cm<\/jats:italic>\n -FHA or\n Cm<\/jats:italic>\n -tea (100\u2009mg\/kg\/7 days) exhibited a significant healing effect on ulcers induced by acetic acid. In the histological analysis, gastric mucosa treated with\n Cm<\/jats:italic>\n -FHA or\n Cm<\/jats:italic>\n -tea advanced restoration of the mucosal epithelium.\n In vitro<\/jats:italic>\n , lower concentrations of\n Cm<\/jats:italic>\n -FHA stimulated cell proliferation in the BrdU assay and cell migration.\n Cm<\/jats:italic>\n -tea and\n Cm<\/jats:italic>\n -FHA present a significant gastric healing effect in\n in vivo<\/jats:italic>\n and\n in vitro<\/jats:italic>\n models.\n <\/jats:p>","DOI":"10.1089\/jmf.2020.0013","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T12:17:24Z","timestamp":1593433044000},"page":"248-257","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cenostigma macrophyllum<\/i>\n Tul. var.\n acuminata<\/i>\n Teles Freire Fraction Leaves Stimulate Gastric Healing in Rats and Human Cell Cultures"],"prefix":"10.1177","volume":"24","author":[{"given":"Ana Fl\u00e1via","family":"Seraine Cust\u00f3dio Viana","sequence":"first","affiliation":[{"name":"Medicinal Plants Research Center, Federal University of Piau\u00ed, Teresina, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio B.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center, Federal University of Piau\u00ed, Teresina, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana H.","family":"Chaves","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Federal University of Piau\u00ed, Teresina, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Viana","sequence":"additional","affiliation":[{"name":"Pathology Laboratory and Forensic Medicine-Favet, State University of Cear\u00e1, Fortaleza, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verlane G.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Laboratory of Antitumor Substances-LSAT, Federal University of Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadne D.","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Laboratory of Antitumor Substances-LSAT, Federal University of Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Candida A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Laboratory of Antitumor Substances-LSAT, Federal University of Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam T.P.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Laboratory of Antitumor Substances-LSAT, Federal University of Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita de C\u00e1ssia M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center, Federal University of Piau\u00ed, Teresina, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13123198"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2011.0025"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/den.12857"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1573(200012)14:8<581::AID-PTR776>3.0.CO;2-S"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2013.786096"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502013000800007"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.08.047"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.02.008"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5198(19)39795-1"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02235252"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.0102"},{"key":"e_1_3_3_14_2","volume-title":"Manual of Techniques for Normal and Pathological Histology [Manual de t\u00e9cnicas para histologia normal e patol\u00f3gica]","author":"Behmer OA","unstructured":"Behmer OA, , Tolosa EMC, , Freitas Neto AG: Manual of Techniques for Normal and Pathological Histology [Manual de t\u00e9cnicas para histologia normal e patol\u00f3gica], 1st ed. 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