{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:32:05Z","timestamp":1788406325200,"version":"build-2803163510"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>\n                    Turmeric extracts (TEs) have been shown to be suitable as a pain treatment for human joint arthritis. In a pilot, randomized clinical trial, 68 individuals with mild\/moderate knee joint pain (KJP) consumed a new formulation of water-soluble TEs and insoluble curcuminoids (B-Turmactive\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ) or brewer's yeast as a placebo for 1 week. Our hypothesis was that B-Turmactive would have a short-term analgesic effect on KJP measured by the self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). After 3 days and 1 week, both treatments reduced pain when walking on a flat surface (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.01), going up or down stairs (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001), and sitting or lying (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05), but only B-Turmactive reduced pain at night while in bed and in an upright standing position (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.01). Concerning global KJP, it was reduced by both treatments after 3 days and 1 week of the intervention (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001), being less with B-Turmactive after 1 week (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.012 vs. 3 weeks). Although no intertreatment differences were observed, only B-Turmactive decreased high-sensitivity C-reactive protein levels (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.045) at 1 week, which indicates a prompt analgesic effect mediated by a decrease in inflammatory status.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2020.0074","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T12:39:31Z","timestamp":1596544771000},"page":"436-440","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial"],"prefix":"10.1177","volume":"24","author":[{"given":"Lorena","family":"Calder\u00f3n-P\u00e9rez","sequence":"first","affiliation":[{"name":"Eurecat, Technological Center of Catalonia, Nutrition and Health Unit, Reus, Spain."},{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-Salut), Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Llaurad\u00f3","sequence":"additional","affiliation":[{"name":"Eurecat, Technological Center of Catalonia, Nutrition and Health Unit, Reus, Spain."},{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-Salut), Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Companys","sequence":"additional","affiliation":[{"name":"Eurecat, Technological Center of Catalonia, Nutrition and Health Unit, Reus, Spain."},{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-Salut), Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pla-Pag\u00e0","sequence":"additional","affiliation":[{"name":"Eurecat, Technological Center of Catalonia, Nutrition and Health Unit, Reus, Spain."},{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-Salut), Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"Boqu\u00e9","sequence":"additional","affiliation":[{"name":"Eurecat, Technological Center of Catalonia, Nutrition and Health Unit, Reus, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Puiggr\u00f3s","sequence":"additional","affiliation":[{"name":"Eurecat, Technological Center of Catalonia, Nutrition and Health Unit, Reus, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa-M","family":"Valls","sequence":"additional","affiliation":[{"name":"Eurecat, Technological Center of Catalonia, Nutrition and Health Unit, Reus, Spain."},{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-Salut), Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pedret","sequence":"additional","affiliation":[{"name":"Eurecat, Technological Center of Catalonia, Nutrition and Health Unit, Reus, Spain."},{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-Salut), Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep Manuel","family":"Llabr\u00e9s","sequence":"additional","affiliation":[{"name":"PLAMECA S.A. (Medicinal Plants and Food Supplements, S.A.), Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Arola","sequence":"additional","affiliation":[{"name":"Eurecat, Technological Center of Catalonia, Nutrition and Health Unit, Reus, Spain."},{"name":"Nutrigenomics Research Group, Faculty of Chemistry, Rovira i Virgili University, Tarragona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sol\u00e0","sequence":"additional","affiliation":[{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-Salut), Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Spain."},{"name":"Intern Medicine Department of Sant Joan de Reus University Hospital, Reus, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.04.045"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.09.002"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2016.3705"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200838"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods6100092"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.12.071"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7100298"},{"key":"e_1_3_6_9_2","first-page":"2473","article-title":"WOMAC: A 20-year experiential review of a patient-centered self-reported health status questionnaire","volume":"29","author":"Bellamy N","year":"2002","unstructured":"Bellamy N: WOMAC: A 20-year experiential review of a patient-centered self-reported health status questionnaire. J Rheumatol, 2002; 29:2473\u20132476.","journal-title":"J Rheumatol"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100670200117"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_3_6_12_2","unstructured":"Valbona C Cuspinera E Violan M Badia E Balagu\u00e9 N Balcells M: Guia de Prescripci\u00f3 d'exercici F\u00edsic per La Salut.; 2007. http:\/\/hdl.handle.net\/11351\/3541 (accessed September 2017)."},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-011-9297-6"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2017.3930"},{"key":"e_1_3_6_15_2","first-page":"1894","article-title":"Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer","volume":"7","author":"Sharma RA","year":"2001","unstructured":"Sharma RA, , McLelland HR, , Hill KA, et al.: Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res, 2001; 7:1894\u20131900.","journal-title":"Clin Cancer Res"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2018.07.001"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-016-1376-9"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.01.002"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu2040449"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-0407.2011.00163.x"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2020.0074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2020.0074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2020.0074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:28:39Z","timestamp":1777645719000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2020.0074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1089\/jmf.2020.0074"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2020.0074","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}