{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:54:57Z","timestamp":1783346097240,"version":"3.54.6"},"reference-count":56,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>\n                    This study was undertaken to investigate the involvement of the reactive oxygen species (ROS) and proinflammatory cytokine production in the pathogenicity of gastrointestinal nematode\n                    <jats:italic toggle=\"yes\">Heligmosomoides polygyrus<\/jats:italic>\n                    in mice and also the protective effect of myrtle (\n                    <jats:italic toggle=\"yes\">Myrtus communis<\/jats:italic>\n                    L.) berry seeds aqueous extract (MBSAE). With this aim, Swiss Albino mice were divided into four groups of 10 animals each: control, helminthiasis, helminthiasis + MBSAE, and helminthiasis + Albendazole. The animals were infected with infective third larval stage (L3) of\n                    <jats:italic toggle=\"yes\">H. polygyrus<\/jats:italic>\n                    by oral administration. Mice were treated with bidistilled water, MBSAE (100\u2009mg\/kg,\n                    <jats:italic toggle=\"yes\">b.w., p.o.<\/jats:italic>\n                    ) or Albendazole (100\u2009mg\/kg,\n                    <jats:italic toggle=\"yes\">b.w., p.o<\/jats:italic>\n                    .). We have demonstrated that MBSAE (100\u2009mg\/kg,\n                    <jats:italic toggle=\"yes\">b.w., p.o.<\/jats:italic>\n                    ) significantly reduced the total mean adult worms compared with the infected and nontreated group. Moreover, hematological parameters, intestinal ROS such as hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), hydroxyl radical (OH\n                    <jats:sup>\u2022<\/jats:sup>\n                    ), and superoxide anion (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    ), as well as serum cytokines such as interleukin (IL)-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    and IL-6 were analyzed. We have shown that\n                    <jats:italic toggle=\"yes\">H. polygyrus<\/jats:italic>\n                    infection has disrupted all these biochemical parameters and that MBSAE treatment has significantly corrected these disturbances. The effect of plant extract was comparable to the standard drug albendazole. Therefore, MBSAE appeared to be a promising agent for the control of intestinal helminthiasis.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2020.0089","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T16:41:57Z","timestamp":1601311317000},"page":"377-384","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of Anti-Inflammatory, Reactive Oxygen Species Scavenging Activity and Nematicidal Properties of Myrtle Berry Seeds on Helminthiasis Treatment"],"prefix":"10.1177","volume":"24","author":[{"given":"Mohamed-Amine","family":"Jabri","sequence":"first","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bioresources, Higher Institute of Biotechnology of Beja, University of Jendouba, Beja, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumaya","family":"Hajaji","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, University of Manouba, National School of Veterinary Medicine of Sidi thabet, Sidi thabet, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka\u00efs","family":"Rtibi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bioresources, Higher Institute of Biotechnology of Beja, University of Jendouba, Beja, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hichem","family":"Sebai","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bioresources, Higher Institute of Biotechnology of Beja, University of Jendouba, Beja, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(95)01298-R"},{"key":"e_1_3_4_3_2","first-page":"69","article-title":"Egg output of Heligmosomoides polygyrus (Nematospiroides dubius) in mice infected once only","volume":"13","author":"Kerboeuf D","year":"1982","unstructured":"Kerboeuf D. 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