{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:42:44Z","timestamp":1777909364414,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n                    Mung bean (\n                    <jats:italic toggle=\"yes\">Vigna radiata<\/jats:italic>\n                    ) is an immunomodulatory medicinal plant, which is recognized as a component of a traditional postpartum diet. The liver plays a crucial role in fatty acid synthesis under the control of various hormones that are affected by pregnancy. This study was designed to establish whether the mung bean water extract, which contains prostaglandins that can regulate corpus luteum maturation, provided any benefits to liver metabolism after the dynamic hormonal change associated with pregnancy. Female C57BL\/6J mice were used, and all mice received daily injections of progesterone (5.0\u2009mg\/kg) for 5 days, after which progesterone was withdrawn for 3 days. Gel-free\/label-free proteomic analysis revealed that the abundance of several proteins was affected in the liver. Hormone manipulation induced changes in lipid metabolism-related protein abundance; oral administration of mung bean coat extract (MBC) for 3 days mitigated the changes and downregulated the expression of\n                    <jats:italic toggle=\"yes\">Cpt1\u03b1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Akr1\u03b2<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Srebp1<\/jats:italic>\n                    in the liver. Together with immunological leukocyte modulation assessed via proteomic analysis, we suggest that MBC may exert health-promoting effects through the modulation of lipid synthesis during postpartum recovery.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2020.4703","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T12:56:06Z","timestamp":1596718566000},"page":"967-977","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Mung Bean (\n                    <i>Vigna radiata<\/i>\n                    (L.)) Coat Extract on Mouse Liver Metabolism During Progesterone Withdrawal"],"prefix":"10.1177","volume":"23","author":[{"given":"Akiko","family":"Hashiguchi","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Tsukuba, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Okabayashi","sequence":"additional","affiliation":[{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisateru","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Tsuchida","sequence":"additional","affiliation":[{"name":"Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Hitachi","sequence":"additional","affiliation":[{"name":"Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Isoda","sequence":"additional","affiliation":[{"name":"Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan."},{"name":"Alliance for Research on the Mediterranean and North Africa (ARENA) University of Tsukuba, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"e_1_3_6_2_2","unstructured":"World Health Organization WHO traditional medicine strategy: 2014\u20132023. 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