{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:17:30Z","timestamp":1788369450824,"version":"build-2803163510"},"reference-count":35,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Nitraria tangutorun<\/jats:italic>\n                    Bobr. has been used for thousands of years as a native folk medicine to alleviate dizziness and neurasthenia due to oxygen. In our previous study, natural antioxidant components (namely, NJBE) were isolated from industrial\n                    <jats:italic toggle=\"yes\">N. tangutorun<\/jats:italic>\n                    Bobr. juice byproducts (NJBE) from the Qinghai-Tibet plateau. The current investigation assessed the effects of NJBE on ischemic stroke in mice and the potential mechanisms. C57BL\/6 mice received NJBE (25, 50, or 100\u2009mg\/Kg) by gavage for 14 days and then stroke was induced by the middle cerebral artery occlusion (MCAO) model, followed by reperfusion for 72\u2009h. The evaluation of brain infarct size, behavioral tests, and functional assessments was conducted to assess the effects of NJBE after MCAO. Our results suggested that NJBE significantly decreases infarct size, improves neurological deficits, as well as reduces the number of GFAP\n                    <jats:sup>+<\/jats:sup>\n                    and Iba-1\n                    <jats:sup>+<\/jats:sup>\n                    cells after MCAO. NJBE inhibited nitric oxide and malondialdehyde production in the ischemic brain. Meanwhile, it attenuated the expressions of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Also, NJBE significantly attenuated the expression levels of proinflammatory indicators, including TNF-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    , IL-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    , IL-6, and IL-12. This process was accompanied by the downregulation of TLR4, TRAF6, pI\n                    <jats:italic toggle=\"yes\">\u03ba<\/jats:italic>\n                    B\/pI\n                    <jats:italic toggle=\"yes\">\u03ba<\/jats:italic>\n                    B, and MMP9 expression and the upregulation of claudin-5 expression. NJBE induced improvements in brain injury. The neuroprotective effect of NJBE provides evidence for its potential application in stroke treatment.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2020.4848","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T16:36:03Z","timestamp":1626712563000},"page":"686-696","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Bioactive Ingredients from\n                    <i>Nitraria tangutorun<\/i>\n                    Bobr. Protect Against Cerebral Ischemia\/Reperfusion Injury Through Attenuation of Oxidative Stress and the Inflammatory Response"],"prefix":"10.1177","volume":"24","author":[{"given":"Hailiang","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Hospital of Jilin University, Changchun, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science of Jilin University, Changchun, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Bi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science of Jilin University, Changchun, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Hospital of Jilin University, Changchun, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuijun","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Jilin University, Changchun, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Ni","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science of Jilin University, Changchun, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.98"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00178A"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2017.10.056"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2017.01.013"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2017.11.008"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.02.053"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.08.055"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.09.093"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826070601084829"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejlt.200900062"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-017-9709-9"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2014.12.054"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00569E"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0496-0"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-10-03449.1990"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.011"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(00)00005-8"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.06.032"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-014-1326-y"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.09.137"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2018.01.004"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2016.11.006"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0652-x"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9604-5"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.01.110"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.008608"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-42667-5_7"},{"key":"e_1_3_4_29_2","first-page":"9","article-title":"Effects of polyphenol-rich interventions on cognition and brain health in healthy young and middle-aged adults: Systematic review and meta-analysis","author":"Ammar A","year":"2020","unstructured":"Ammar A, , Trabelsi K, , Boukhris O, et al.: Effects of polyphenol-rich interventions on cognition and brain health in healthy young and middle-aged adults: Systematic review and meta-analysis. 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