{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:43:00Z","timestamp":1777909380075,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    In Mexico, Cactaceae plants are widely used in folk medicine for the treatment of diabetes. The genus\n                    <jats:italic toggle=\"yes\">Opuntia<\/jats:italic>\n                    spp.\n                    <jats:italic toggle=\"yes\">Opuntia matudae<\/jats:italic>\n                    Sheinvar prickly pears are known as xoconostle and are used in Mexican cuisine for their acidic flavor. Currently there are few reports of pharmacological properties of this plant, which include antioxidant and antimicrobial activities. This study focuses on the chemical characterization of the methanolic (OmMe) and aqueous (OmAq) extracts and the evaluation of the antidiabetic activity of\n                    <jats:italic toggle=\"yes\">O. matudae<\/jats:italic>\n                    fruits in two biological models.\n                  <\/jats:p>\n                  <jats:p>\n                    For the\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    model, streptozotocin (STZ)-induced diabetic mice were used, and for the\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    model, liver sections isolated from healthy mice were used. The OmAq (100\u2009mg\/kg, oral pathway [p.o.]) extract decreased postprandial glucose peak at 0.5\u2009h after glucose uptake by 43.1%, similarly, OmMe (100\u2009mg\/kg, p.o.) extract reduced postprandial glucose peak at 0.5\u2009h by 34.1% in healthy mice. The effect of the two extracts and the fraction of the mixture of unidentified betalains (OmB) of\n                    <jats:italic toggle=\"yes\">O. matudae<\/jats:italic>\n                    evaluated in the isolated mouse liver slice model showed a concentration-dependent decrease in hepatic glucose output (HGO) with and without insulin administration with the OmMe extract. The OmAq extract, however, showed concentration-dependent increases of HGO with and without insulin, and the OmB fraction generally exhibited an insulin mimetic effect. Moreover, both OmAq and OmMe extracts were tested in mice with STZ-induced diabetes (160\u2009mg\/kg, intraperitoneal route), using a semichronic daily administration (2\u201328 days after diabetes onset) of OmAq extract was able to reduce blood glucose by 34.3%, meanwhile OmMe extract reduced blood glucose by 22.9%, 28 days after diabetes onset. We identified five compounds (\n                    <jats:bold>1\u20135<\/jats:bold>\n                    ) in the two extracts, consisting of two phenolic acids (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    ), three flavanols (\n                    <jats:bold>3\u20135<\/jats:bold>\n                    ), as well as two unidentified betalains. Therefore, we conclude that the aqueous extract of the xoconostle fruit where betalains are present may be useful for the treatment of diabetes mellitus.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2021.0041","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T10:21:53Z","timestamp":1642155713000},"page":"70-78","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Antidiabetic Activity of Xoconostle Fruit from\n                    <i>Opuntia matudae<\/i>\n                    Scheivar in Mice"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1670","authenticated-orcid":false,"given":"Manas\u00e9s","family":"Gonz\u00e1lez-Cortazar","sequence":"first","affiliation":[{"name":"South Biomedical Research Center, Mexican Institute of Social Security (IMSS), Xochitepec, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Silvia","family":"Guti\u00e9rrez-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"South Biomedical Research Center, Mexican Institute of Social Security (IMSS), Xochitepec, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Vargas-Ruiz","sequence":"additional","affiliation":[{"name":"South Biomedical Research Center, Mexican Institute of Social Security (IMSS), Xochitepec, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Mariana","family":"Montiel-Ruiz","sequence":"additional","affiliation":[{"name":"South Biomedical Research Center, Mexican Institute of Social Security (IMSS), Xochitepec, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ever A.","family":"Ble-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Academic Division of Basic Sciences, Autonomous Ju\u00e1rez University of Tabasco, Cunduac\u00e1n, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda Yamila","family":"P\u00e9rez-Ter\u00e1n","sequence":"additional","affiliation":[{"name":"South Biomedical Research Center, Mexican Institute of Social Security (IMSS), Xochitepec, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Tortoriello","sequence":"additional","affiliation":[{"name":"South Biomedical Research Center, Mexican Institute of Social Security (IMSS), Xochitepec, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-8274","authenticated-orcid":false,"given":"Enrique","family":"Jim\u00e9nez-Ferrer","sequence":"additional","affiliation":[{"name":"South Biomedical Research Center, Mexican Institute of Social Security (IMSS), Xochitepec, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"1","volume-title":"Diabetes and the Eye: Latest Concepts and Practices","author":"Hendrick AM","year":"2021","unstructured":"Hendrick AM: Diabetes epidemic, epidemiology, statistics and trends. 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