{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:54:38Z","timestamp":1781560478540,"version":"3.54.5"},"reference-count":45,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>\n                    Since low serum\n                    <jats:bold>\n                      <jats:sc>l<\/jats:sc>\n                    <\/jats:bold>\n                    -arginine (Arg) and high asymmetric dimethylarginine (ADMA) can predict microvascular complications in type 2 diabetes mellitus (T2DM), we tested whether Arg and ADMA are affected by diet and physical activity in overweight\/obese and T2DM subjects. We tested the effects on serum Arg and ADMA of single loads of dextrose, protein, fat, or alcohol (\u223c300 calories each); one episode of physical exercise; and 12 weeks of standard lifestyle modification (dietary and physical activity counseling). Alcohol drink was followed by \u223c30% lowering in Arg. Arg and ADMA increased after a protein load but remained stable after glucose or fat load or 30\u2009min of treadmill walk. Following 12 weeks of lifestyle modification, ADMA declined only in subjects achieving weight loss &gt;5%. In conclusion, alcohol is a previously unrecognized acute suppressor of serum Arg. Lifestyle modification lowers ADMA in subjects who achieve weight loss &gt;5%.\n                  <\/jats:p>\n                  <jats:p>Clinical Trial Registration Number: NCT04406402.<\/jats:p>","DOI":"10.1089\/jmf.2021.0045","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T10:56:11Z","timestamp":1655376971000},"page":"675-682","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Alcohol Drinks Induce Acute Lowering in Circulating\n                    <scp>l<\/scp>\n                    -Arginine in Obese and Type 2 Diabetic Subjects"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4412-6532","authenticated-orcid":false,"given":"Assaf","family":"Buch","sequence":"first","affiliation":[{"name":"The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center."},{"name":"The Sagol Center for Epigenetics of Metabolism and Aging, The Institute of Endocrinology, Metabolism and Hypertension; Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Ganz","sequence":"additional","affiliation":[{"name":"Diabetes Unit, E. Wolfson Medical Center, Holon, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Wainstein","sequence":"additional","affiliation":[{"name":"Diabetes Unit, E. Wolfson Medical Center, Holon, Israel."},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Gilad","sequence":"additional","affiliation":[{"name":"The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona","family":"Limor","sequence":"additional","affiliation":[{"name":"The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabi","family":"Shefer","sequence":"additional","affiliation":[{"name":"The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center."},{"name":"The Sagol Center for Epigenetics of Metabolism and Aging, The Institute of Endocrinology, Metabolism and Hypertension; Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3920-7549","authenticated-orcid":false,"given":"Mona","family":"Boaz","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences, Ariel University, Ariel, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5123-3176","authenticated-orcid":false,"given":"Naftali","family":"Stern","sequence":"additional","affiliation":[{"name":"The Sagol Center for Epigenetics of Metabolism and Aging, The Institute of Endocrinology, Metabolism and Hypertension; Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0822-4"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00284.2012"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-924966"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(00)00320-X"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x02vm434ra"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3169"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1825-9"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.02.010"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(03)00089-1"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200111260"},{"key":"e_1_3_6_12_2","first-page":"33","article-title":"Serum asymmetric dimethylarginine and arginine levels predict microvascular and macrovascular complications in type 2 diabetes mellitus","author":"Ganz T","year":"2017","unstructured":"Ganz T, , Wainstein J, , Gilad S, , Limor R, , Boaz M, , Stern N: Serum asymmetric dimethylarginine and arginine levels predict microvascular and macrovascular complications in type 2 diabetes mellitus. 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