{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:54:38Z","timestamp":1781560478548,"version":"3.54.5"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    Group A Streptococci (GAS) or\n                    <jats:italic toggle=\"yes\">Streptococcus pyogenes<\/jats:italic>\n                    is responsible for acute bacterial pharyngitis in children as well as adults. Streptococcal pharyngitis is initiated by successful attachment and colonization of the bacteria, followed by the establishment of the biofilm in various environments. In this study, we examined the antibacterial activities of in-house prepared aqueous and ethanolic extracts of 10 Atlantic Canada fruits in the context of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), time\u2013kill kinetics, and adhesion inhibition properties against\n                    <jats:italic toggle=\"yes\">S. pyogenes<\/jats:italic>\n                    . Per our findings, MIC and MBC for all the tested extracts ranged from 0.25 to 8\u2009mg\/mL and from 4 to 64\u2009mg\/mL, respectively. Accordingly, at 1\u20442\u2009\u00d7\u2009MBC, cranberry and sumac extracts also lowered the attachment of GAS to the uncoated and fibronectin-coated substratum. Particularly, cranberry and sumac aqueous extracts were more effective against the adhesion of\n                    <jats:italic toggle=\"yes\">S. pyogenes<\/jats:italic>\n                    ATCC 19615 to the fibronectin-coated surface than a clinical strain. In conclusion, ethanolic and aqueous extracts of cranberry and sumac could potentially be incorporated into natural health products designed for the amelioration of strep throat, yet a detailed understanding of its mode of action (\n                    <jats:italic toggle=\"yes\">e.g.<\/jats:italic>\n                    , biofilm inhibition and eradication) could pave its path to the field of antibacterial natural health product discovery, design, and development.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2021.0047","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T09:07:11Z","timestamp":1643101631000},"page":"426-434","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cranberry and Sumac Extracts Exhibit Antibacterial and Anti-Adhesive Effects Against\n                    <i>Streptococcus pyogenes<\/i>"],"prefix":"10.1177","volume":"25","author":[{"given":"Soheila","family":"Abachi","sequence":"first","affiliation":[{"name":"Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, Nova Scotia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Mac\u00e9","sequence":"additional","affiliation":[{"name":"IFREMER, BRM, EM3B Laboratory, Nantes, CEDEX 3, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.P. Vasantha","family":"Rupasinghe","sequence":"additional","affiliation":[{"name":"Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, Nova Scotia, Canada."},{"name":"Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"51","article-title":"Update on the management of streptococcal pharyngitis","volume":"38","author":"Chahine EB","year":"2013","unstructured":"Chahine EB, , Sucher AJ: Update on the management of streptococcal pharyngitis. US Pharm, 2013; 38:51\u201356.","journal-title":"US Pharm"},{"key":"e_1_3_4_3_2","first-page":"11","article-title":"Antibiotic resistance threats in the United States","author":"Frieden T","year":"2013","unstructured":"Frieden T: Antibiotic resistance threats in the United States. 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