{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:54:41Z","timestamp":1781560481501,"version":"3.54.5"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    Pediatric Crohn's disease (CD) is commonly associated with hepatobiliary complications, including transient liver enzymes elevation (LEE). Exclusive enteral nutrition (EEN) is recommended as primary treatment in mild-to-moderate pediatric CD. Data concerning EEN and liver enzymes (LE) abnormalities are limited. The aim of this study was to assess the LEE occurrence in newly diagnosed CD pediatric patients during EEN. Retrospective analysis of 73 patients, with no previous signs of liver disease, qualified to EEN. LE were assessed at diagnosis, during EEN, after completion of the nutritional treatment, and reintroduction of free diet. Thirty-one (42%) children presented with LEE and 28 (38%) with transient LEE. The LEE cohort presented with higher percentage of protein energy (24.0%\u2009\u00b1\u200929.4 IQR [interquartile range] vs. 18.6%\u2009\u00b1\u200923.6 IQR,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05) versus nonprotein energy (fat and carbohydrates) in total energy intake (75.9%\u2009\u00b1\u200929.4 IQR vs. 81.4%\u2009\u00b1\u200923.6 IQR,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Also, the protein\/energy ratio was higher in the LEE group compared with the group with normal LE (0.026 vs. 0.024,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.028). At the fourth week of EEN, aspartate aminotransferase elevation correlated with higher daily protein intake (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.018). The LEE during EEN is typically a low-grade and transient condition that may be connected to applied treatment. We hypothesize that higher protein\/energy ratio during EEN may be associated with mild, temporary LEE. Careful observation with repeated measurement of LE activity may be sufficient proceeding in patients without any other symptoms of CD-associated liver disease.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2021.0069","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T09:07:29Z","timestamp":1643101649000},"page":"402-407","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Exclusive Enteral Nutrition Remission Induction Treatment Influence on Transient Hypertransaminasemia in Children with Newly Onset Crohn's Disease"],"prefix":"10.1177","volume":"25","author":[{"given":"Agata","family":"Wasilewska","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gastroenterology and Nutrition, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Ponanta-Gawron","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gastroenterology and Nutrition, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Burtan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gastroenterology and Nutrition, University Chlildren's Hospital, Krakow, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charissa","family":"Stephen Chandra Sagaran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gastroenterology and Nutrition, University Chlildren's Hospital, Krakow, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Duplaga","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and e Health, Faculty of Health Sciences, Institute of Public Health, Jagiellonian University Medical College, Krakow, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Kowalska-Duplaga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gastroenterology and Nutrition, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000672"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000409"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2019.01.06"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i22.6809"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.33590\/emjgastroenterol\/10314458"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000239"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.143"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21493"},{"key":"e_1_3_3_10_2","first-page":"690","article-title":"Reference flow chart of height, body mass and body mass index in children and adolescent in Poland\u2013OLAF research (Siatki centylowe wysoko\u015bci, masy cia\u0142a i wska\u017anika masy cia\u0142a dzieci i m\u0142odzie\u017cy w Polce \u2013 wyniki badania OLAF)","volume":"7","author":"Ku\u0142aga Z","year":"2010","unstructured":"Ku\u0142aga Z, , R\u00f3\u017cd\u017cy\u0144ska A, , Palczewska I, et al.: Reference flow chart of height, body mass and body mass index in children and adolescent in Poland\u2013OLAF research (Siatki centylowe wysoko\u015bci, masy cia\u0142a i wska\u017anika masy cia\u0142a dzieci i m\u0142odzie\u017cy w Polce \u2013 wyniki badania OLAF). 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