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The molecular etiology of sarcopenia is complex, but physical inactivity, poor diet, and age diminished ability to stimulate muscle protein synthesis (MPS) remain important drivers. A body of evidence shows that, acting through the highly conserved nutrient sensor pathway mTORc1, the branch chain amino acid leucine can trigger and enhance MPS in older adults, and thus has a role in the medical management of sarcopenia. Whey protein-enriched enteral supplements are a low cost, easily accessible source of highly bioavailable leucine used clinically in older adults for preservation of lean body mass in long-term care setting. Therefore, given the evidence of leucine's ability to stimulate MPS in older adults, we argue that meal supplementation with whey-enriched enteral products, which can provide the 3\u20135\u2009g of leucine necessary to trigger MPS in older adults, should be given serious consideration by medical and nutrition professionals to potentially mitigate muscle wasting and sarcopenia risk associated with prolonged COVID-19 lockdown measures.<\/jats:p>","DOI":"10.1089\/jmf.2021.0094","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T11:48:46Z","timestamp":1635508126000},"page":"117-120","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["mTOR1c Activation with the Leucine \u201cTrigger\u201d for Prevention of Sarcopenia in Older Adults During Lockdown"],"prefix":"10.1177","volume":"25","author":[{"given":"Karen","family":"Mai","sequence":"first","affiliation":[{"name":"Urban Public Health and Nutrition Program, Hunter College, City University of New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Cando","sequence":"additional","affiliation":[{"name":"Urban Public Health and Nutrition Program, Hunter College, City University of New York, New York, USA."},{"name":"Flushing Hospital Medical Center, Flushing, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-3582","authenticated-orcid":false,"given":"Steven E.","family":"Trasino","sequence":"additional","affiliation":[{"name":"Urban Public Health and Nutrition Program, Hunter College, City University of New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv211"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061583"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6915e3"},{"key":"e_1_3_4_6_2","unstructured":"Cdcgov: Risk for COVID-19 Infection Hospitalization and Death By Age Group | CDC. @CDCgov. 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