{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:43:25Z","timestamp":1777909405338,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Schisandra chinensis<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">S. chinensis<\/jats:italic>\n                    ) is one of the core drugs used for relieving cough and asthma in traditional Chinese medicine. However, there are few basic studies on the treatment of respiratory diseases with\n                    <jats:italic toggle=\"yes\">S. chinensis<\/jats:italic>\n                    in modern pharmacology, and the material basis and mechanism of its antiasthmatic effect are still unclear. Lignans are the main active components of\n                    <jats:italic toggle=\"yes\">S. chinensis<\/jats:italic>\n                    . The aim of this study was to observe the relaxation effect of\n                    <jats:italic toggle=\"yes\">S. chinensis<\/jats:italic>\n                    lignans (SCL) on the tracheal smooth muscle of rats by\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    tracheal perfusion experiments, and to explore the mechanism by preincubation with L-type calcium channel blocker verapamil, four potassium channel blockers glibenclamide, tetraethylamine, 4-aminopyridine and barium chloride (BaCl\n                    <jats:sub>2<\/jats:sub>\n                    ),\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -adrenoceptor blocker propranolol, nitric oxide synthase inhibitor N\u03c9-nitro-L-arginine methyl ester (L-NAME), and the cyclooxygenase inhibitor indomethacin, respectively. The results showed that SCL (0.25\u20131.75\u2009mg\/mL) reduced the contraction of isolated tracheal smooth muscle induced by acetylcholine, the preincubation with verapamil and glibenclamide could attenuate the relaxation effect, whereas propranolol, 4-aminopyridine, BaCl\n                    <jats:sub>2<\/jats:sub>\n                    , tetraethylamine, L-NAME, and indomethacin had no such effect. These results suggest that SCL has a significant relaxation effect on the isolated tracheal smooth muscle of rats, and the mechanism may be related to the inhibition of extracellular calcium influx and intracellular calcium release from the sarcoplasmic reticulum, as well as the activation of ATP-sensitive potassium channels. These findings may provide a pharmacological basis for the traditional use of\n                    <jats:italic toggle=\"yes\">S. chinensis<\/jats:italic>\n                    to treat asthma.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2021.k.0037","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T16:58:21Z","timestamp":1629305901000},"page":"825-832","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Relaxation Effect of\n                    <i>Schisandra Chinensis<\/i>\n                    Lignans on the Isolated Tracheal Smooth Muscle in Rats and Its Mechanism"],"prefix":"10.1177","volume":"24","author":[{"given":"Cheng-Cheng","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi-Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Yue","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Test Technique, College of Medical Technology, Beihua University, Jilin, Jilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Guang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"Chinese Pharmacopoeia Commission: Pharmacopoeia of the People's Republic of Chinavol. 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