{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:54:32Z","timestamp":1781560472393,"version":"3.54.5"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    We examined the efficacy of fermented\n                    <jats:italic toggle=\"yes\">Curcuma longa<\/jats:italic>\n                    L. (FT) on the development of alcoholic fatty liver in mice and investigated the underlying mechanism. The protective potential of FT against ethanol-induced fatty liver was determined using C57BL\/6 male mice allocated into four groups (8 mice\/group). Control groups received either distilled water or 5\u2009g\/kg body weight (b.w.) per day ethanol for 8 days. Treatment groups were administered either 300\u2009mg\/kg b.w. per day of milk thistle or FT before receiving ethanol. FT contained a higher amount of caffeic acid and tetrahydrocurcumin than\n                    <jats:italic toggle=\"yes\">C. longa<\/jats:italic>\n                    . FT pretreatment significantly suppressed the elevated hepatic lipid droplets associated with ethanol ingestion. In comparison with ethanol-treated control, FT pretreated mice showed inhibited cytochrome P4502E1 (CYP2E1), sterol regulatory element-binding protein-1 (SREBP-1c), and acetyl-CoA carboxylase production but elevated AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha (PPAR-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    ), and carnitine palmitoyltransferase 1 (CPT-1) levels. Taken together, FT is a promising hepatoprotectant for preventing of alcoholic fatty liver through modulating fatty acid synthesis and oxidation.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2021.k.0098","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T11:40:35Z","timestamp":1650368435000},"page":"456-463","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Fermented\n                    <i>Curcuma longa<\/i>\n                    L. Prevents Alcoholic Fatty Liver Disease in Mice by Regulating CYP2E1, SREBP-1c, and PPAR-\n                    <i>\u03b1<\/i>"],"prefix":"10.1177","volume":"25","author":[{"given":"Moeun","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Food and Nutrition, Chonnam National University, Gwangju, Korea,"},{"name":"Process Development and Fermentation Group, World Institute of Kimchi, Gwangju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hee","family":"Nam","sequence":"additional","affiliation":[{"name":"Institute of Agricultural Science and Technology, Chonnam National University, Gwangju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Geun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, Yonsei University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintae","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Food and Nutrition, Chonnam National University, Gwangju, Korea,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghee","family":"You","sequence":"additional","affiliation":[{"name":"Division of Food and Nutrition, Chonnam National University, Gwangju, Korea,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Chul","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-0132","authenticated-orcid":false,"given":"Yoo-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, University of Suwon, Suwon, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongjin","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Food and Nutrition, Chonnam National University, Gwangju, Korea,"},{"name":"Research Institute for Human Ecology, Chonnam National University, Gwangju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woojin","family":"Jun","sequence":"additional","affiliation":[{"name":"Division of Food and Nutrition, Chonnam National University, Gwangju, Korea,"},{"name":"Research Institute for Human Ecology, Chonnam National University, Gwangju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"84","article-title":"Alcohol and the liver: Metabolism of alcohol and its role in hepatic and extrahepatic diseases","volume":"67","author":"Lieber CS","year":"2000","unstructured":"Lieber CS: Alcohol and the liver: Metabolism of alcohol and its role in hepatic and extrahepatic diseases. 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