{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:43:27Z","timestamp":1777909407678,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    We investigated the effects of bonito fish (\n                    <jats:italic toggle=\"yes\">Katsuwonus pelamis<\/jats:italic>\n                    ) elastin HC (KE) on skin dryness, wrinkles, and pigmentation\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    .\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    , we evaluated the expression of mRNA genes and proteins related to skin dryness, wrinkles, and pigmentation. HaCaT and HS27 cells were exposed to ultraviolet B radiation (UVB) (50\u2009mJ\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ), and B16F10 cells were stimulated with 3-isobutyl-1-methylxanthine (IBMX, 250\u2009\u03bcg\/mL) for 72\u2009h to induce melanin synthesis. All cells were treated with KE (50\u2013400\u2009\u03bcg\/mL) for 24\u2009h. We found that KE increased the expression of long-chain base 1, dihydroceramide desaturase 1, elastin, hyaluronan synthase 2, and ceramide synthase 4 mRNA or protein as well as hyaluronic acid and sphingomyelin levels in UVB-irradiated HaCaT cells. Moreover, KE regulated factors related to collagen production, wrinkles, and melanin production in UVB-irradiated HS27 cells and IBMX-stimulated B16F10 cells.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>In vivo<\/jats:title>\n                    <jats:p>, we evaluated skin hydration and the expression of mRNA genes and proteins in the skin, and conducted morphological observations in SKH-I hairless mice (5-week-old male). The mice were exposed stepwise to UVB and given KE (10, 20, and 30\u2009mg\/kg b.w.) for 8 weeks. We found that skin hydration and protein or mRNA expression related to skin moisturization were increased in the KE group. Moreover, KE intake increased factors related to collagen production, wrinkles, and melanin production in UVB-irradiated SKH-I hairless mice. These results suggest that KE may have efficacy for the development of treatments for improving skin health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jmf.2021.k.0120","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T10:21:53Z","timestamp":1642155713000},"page":"48-60","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Bonito Elastin HC on Skin Dryness, Wrinkles, and Pigmentation\n                    <i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>"],"prefix":"10.1177","volume":"25","author":[{"given":"Soo-Jeung","family":"Park","sequence":"first","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dakyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minhee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaeeun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangwon","family":"Eun","sequence":"additional","affiliation":[{"name":"R&amp;D Division, Daehan Chemtech Co. 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