{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:22:11Z","timestamp":1785453731917,"version":"3.56.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    Uric acid is the final product of purine metabolism in human. The increase of serum uric acid is tightly related to the incidence of hyperuricemia and gout. Also, it has been reported that the intake of purine-rich foods like meat and seafood is associated with an increased risk of gout. Therefore, the reduction of purine absorption is one of therapeutic approaches to prevent hyperuricemia and gout. Currently, probiotics are being studied for the management of hyperuricemia and gout. In this study, we aimed to investigate the effect of\n                    <jats:italic toggle=\"yes\">Lactobacillus brevis<\/jats:italic>\n                    MJM60390 on hyperuricemia induced by a high-purine diet and potassium oxonate in a mouse model.\n                    <jats:italic toggle=\"yes\">L. brevis<\/jats:italic>\n                    MJM60390 among 24 lactic acid bacteria isolated from fermented foods showed the highest ability to assimilate inosine and guanosine\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and typical probiotic characteristics, like the absence of bioamine production, D-lactate production, hemolytic activity, as well as tolerance to simulated orogastrointestinal conditions and adherence to Caco-2 cells. In an\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    animal study, the uric acid level in serum was significantly reduced to a normal level after oral administration of\n                    <jats:italic toggle=\"yes\">L. brevis<\/jats:italic>\n                    MJM60390 for 2 weeks. The activity of xanthine oxidase catalyzing the formation of uric acid was also inhibited by 30%. Interestingly, damage to the glomerulus, Bowman's capsule, and tubules in the hyperuricemia model were reversed by supplementation with this strain. Fecal microbiome analysis revealed that\n                    <jats:italic toggle=\"yes\">L. brevis<\/jats:italic>\n                    MJM60390 supplementation enhanced the relative abundance of the\n                    <jats:italic toggle=\"yes\">Rikenellaceae<\/jats:italic>\n                    family, which produces the short-chain fatty acid butyrate and helps to maintain good gut condition. Therefore, these results demonstrated that\n                    <jats:italic toggle=\"yes\">L. brevis<\/jats:italic>\n                    MJM60390 can be a probiotic candidate to prevent hyperuricemia.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2021.k.0171","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T11:40:35Z","timestamp":1650368435000},"page":"367-380","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Probiotic Characterization of\n                    <i>Lactobacillus brevis<\/i>\n                    MJM60390 and\n                    <i>In Vivo<\/i>\n                    Assessment of Its Antihyperuricemic Activity"],"prefix":"10.1177","volume":"25","author":[{"given":"Youjin","family":"Lee","sequence":"first","affiliation":[{"name":"Graduate School of Interdisciplinary Program of Biomodulation, and Myongji University, Yongin-si, Gyeonggi-Do, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neagawooridwimeu","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of Interdisciplinary Program of Biomodulation, and Myongji University, Yongin-si, Gyeonggi-Do, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Werlinger","sequence":"additional","affiliation":[{"name":"Graduate School of Interdisciplinary Program of Biomodulation, and Myongji University, Yongin-si, Gyeonggi-Do, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-A","family":"Suh","sequence":"additional","affiliation":[{"name":"Graduate School of Interdisciplinary Program of Biomodulation, and Myongji University, Yongin-si, Gyeonggi-Do, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanki","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate School of Interdisciplinary Program of Biomodulation, and Myongji University, Yongin-si, Gyeonggi-Do, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Hyung","family":"Cho","sequence":"additional","affiliation":[{"name":"Graduate School of Interdisciplinary Program of Biomodulation, and Myongji University, Yongin-si, Gyeonggi-Do, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-6882","authenticated-orcid":false,"given":"Jinhua","family":"Cheng","sequence":"additional","affiliation":[{"name":"Graduate School of Interdisciplinary Program of Biomodulation, and Myongji University, Yongin-si, Gyeonggi-Do, Korea."},{"name":"Myongji Bioefficacy Research Center, Myongji University, Yongin-si, Gyeonggi-Do, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)56639-4"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/53.3.665"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-4-12"},{"key":"e_1_3_5_5_2","unstructured":"Healthcare bigdata hub: http:\/\/opendata.hira.or.kr\/op\/opc\/olapMfrnIntrsIlnsInfo.do (accessed October18 2021)."},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0441-1"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000343567"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2013.03.005"},{"key":"e_1_3_5_9_2","article-title":"High serum uric acid and increased risk of type 2 diabetes: A systemic review and meta-analysis of prospective cohort studies","volume":"8","author":"Lv Q","year":"2013","unstructured":"Lv Q, , Meng XF, , He FF, et al.: High serum uric acid and increased risk of type 2 diabetes: A systemic review and meta-analysis of prospective cohort studies. 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