{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:43:32Z","timestamp":1777909412790,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aloysia polystachya<\/jats:italic>\n                    is a plant species that is widely used in Brazilian folk medicine for the treatment of different disorders that affect the cardiovascular system. The aim of the study was to investigate the cardioprotective effects of an ethanol-soluble fraction of\n                    <jats:italic toggle=\"yes\">A. polystachya<\/jats:italic>\n                    (ESAP) on isoproterenol-induced myocardial infarction in rats. Different groups of rats (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20098) were orally treated with ESAP (30, 100, and 300\u2009mg\/kg), carvedilol (10\u2009mg\/kg), or vehicle (filtered water; 1\u2009mL\/100\u2009g) for 7 days. Naive rats received no treatment. On the morning of day 6, acute myocardial infarction was induced by the acute oral administration of isoproterenol (100\u2009mg\/kg). On the morning of day 8, all rats underwent electrocardiography and transthoracic echocardiography. Blood samples were then collected, and serum levels of creatine kinase-MB fraction (CK-MB) and cardiac troponin T (cTNT) were quantified. ESAP significantly reduced electrocardiographic changes, improved the ventricular ejection fraction, and reduced serum levels of CK-MB and cTNT in infarcted rats. The cardioprotective effects of ESAP could be exploited as an effective tool against isoproterenol-induced myocardial infarction in rats.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2022.0027","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T10:43:58Z","timestamp":1673606638000},"page":"36-39","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Evidence of the Cardioprotective Effects of\n                    <i>Aloysia polystachya<\/i>\n                    in Isoproterenol-Induced Myocardial Infarction in Rats"],"prefix":"10.1177","volume":"26","author":[{"given":"Karyne Garcia Tafarelo","family":"Moreno","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Lima","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Aparecida Macedo","family":"Marques","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Donadel","sequence":"additional","affiliation":[{"name":"Laboratory of Pre-Clinical Research of Natural Products, Postgraduate Program in Animal Science with Emphasis on Bioactive Products, Paranaense University, Umuarama, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emerson Luiz Botelho","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Laboratory of Pre-Clinical Research of Natural Products, Postgraduate Program in Animal Science with Emphasis on Bioactive Products, Paranaense University, Umuarama, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Ayr Tavares","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-5098","authenticated-orcid":false,"given":"Arquimedes","family":"Gasparotto","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10943-018-0713-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114077"},{"key":"e_1_3_4_4_2","first-page":"46","article-title":"Caracterizaci\u00f3n fisicoqu\u00edmica y actividad antioxidante de un extracto etan\u00f3lico de Aloysia polystachya (Griseb.) Mold. (Verbenaceae)","volume":"44","author":"Aguado MI","year":"2013","unstructured":"Aguado MI, , Nu\u00f1ez MB, , Bela AJ, et al. Caracterizaci\u00f3n fisicoqu\u00edmica y actividad antioxidante de un extracto etan\u00f3lico de Aloysia polystachya (Griseb.) Mold. (Verbenaceae). Rev Mex Cienc Farm, 2013; 44: 46\u201351.","journal-title":"Rev Mex Cienc Farm"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.01.033"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112060"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2007.11.018"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.09.007"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1669676"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201720160457"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-2042-4"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom9110664"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2015.0243"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S166157"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.05.002"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq446"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.08.013"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.20319"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.2.790"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00212-5"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.20.2338"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.08.009"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-019-00338-4"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2013.02.005"},{"issue":"1","key":"e_1_3_4_25_2","first-page":"56","article-title":"Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in wistar rats","volume":"201316","author":"Mehdizadeh R","unstructured":"Mehdizadeh R, , Parizadeh MR, , Khooei AR, et al. Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in wistar rats. 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