{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:49:47Z","timestamp":1787240987954,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n                    Patchouli alcohol (PA) is a tricyclic sesquiterpene and the dominant bioactive component in oil extracted from the aerial parts of\n                    <jats:italic toggle=\"yes\">Pogostemon cablin<\/jats:italic>\n                    (patchouli). It has been reported to possess diverse health-beneficial activities, including anti-inflammatory, antiobese, and anticancer activities. However, preclinical studies are required to explore the possibility of developing PA as a promising functional and promising drug for the prevention and treatment of human diseases. In this study, we used animal models to examine whether PA shows benefits in inflammation-induced colorectal cancer and obesity-induced diabetes.\n                    <jats:italic toggle=\"yes\">\n                      Apc\n                      <jats:sup>Min\/+<\/jats:sup>\n                    <\/jats:italic>\n                    mice for colorectal cancer model were treated PA 0, 25 and 50\u2009mg\/kg body weight three times a week for 6 weeks along with 2% dextran sulfate sodium (DSS) in drinking water for 1 week. High-fat diet (HFD)-induced obesity mice were treated with PA 0, 25, and 50\u2009mg\/kg bodyweight three times a week for 8 weeks. Oral administration of PA to\n                    <jats:italic toggle=\"yes\">\n                      Apc\n                      <jats:sup>Min\/+<\/jats:sup>\n                    <\/jats:italic>\n                    mice treated with DSS significantly suppressed formation and development of tumors in both small and large intestines. In cell culture using Caco-2 human colorectal cancer cells, treatment of culture media with PA suppressed proliferation and induced G1-phase growth arrest. In a mouse model of HFD-induced obesity, glucose tolerance tests indicated the same orally administered dose of PA to significantly reduce blood glucose.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    assays in differentiated C2C12 myocytes further demonstrated PA to significantly enhance glucose uptake and increase phosphorylation of 5\u2032 adenosine monophosphate-activated protein kinase and protein kinase B. This study demonstrates that PA might possess health beneficial effects on colorectal cancer and obesity-induced diabetes.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2022.0130","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T13:24:21Z","timestamp":1681824261000},"page":"255-261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Preventive Activity of Patchouli Alcohol Against Colorectal Cancer and Diabetes"],"prefix":"10.1177","volume":"26","author":[{"given":"Jihye","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Seop","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"e_1_3_4_2_2","article-title":"Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review","volume":"89","author":"Lee HS","year":"2020","unstructured":"Lee HS, , Lee J, , Smolensky D, , Lee SH. Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review. 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