{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:43:55Z","timestamp":1777909435927,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                    modulates the host inflammatory response, resulting in chronic gastritis, which contributes to gastric cancer pathogenesis. We verified the effect of\n                    <jats:italic toggle=\"yes\">Cudrania tricuspidata<\/jats:italic>\n                    on\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    infection by inhibiting\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    -induced inflammatory activity. Five-week-old C57BL\/6 mice (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20098) were administered\n                    <jats:italic toggle=\"yes\">C. tricuspidata<\/jats:italic>\n                    leaf extract (10 or 20\u2009mg\/kg per day) for 6 weeks. An invasive test (campylobacter-like organism [CLO]) and noninvasive tests (stool antigen test [SAT] and\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    antibody enzyme-linked immunosorbent assay) were performed to confirm the eradication of\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    . To evaluate the anti-inflammatory effect of\n                    <jats:italic toggle=\"yes\">C. tricuspidata,<\/jats:italic>\n                    pro-inflammatory cytokines levels and inflammation scores were measured in mouse gastric tissue.\n                    <jats:italic toggle=\"yes\">C. tricuspidata<\/jats:italic>\n                    significantly decreased the CLO score and\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    immunoglobulin G antibody optical density levels at both 10 and 20\u2009mg\/kg per day doses (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05).\n                    <jats:italic toggle=\"yes\">C. tricuspidata<\/jats:italic>\n                    decreased the\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    antibody levels in a concentration-dependent manner, increased negative responses to SAT by up to 37.5%, and inhibited the pro-inflammatory cytokines interleukin (IL; IL-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    , IL-6, 1L-8, and tumor necrosis factor alpha).\n                    <jats:italic toggle=\"yes\">C. tricuspidata<\/jats:italic>\n                    also relieved gastric erosions and ulcers and significantly reduced the inflammation score (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). We measured rutin in\n                    <jats:italic toggle=\"yes\">C. tricuspidata<\/jats:italic>\n                    extract as a standard for high-performance liquid chromatography.\n                    <jats:italic toggle=\"yes\">C. tricuspidata<\/jats:italic>\n                    leaf extract showed anti-\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    activity through the inhibition of inflammation. Our findings suggest that\n                    <jats:italic toggle=\"yes\">C. tricuspidata<\/jats:italic>\n                    leaf extract is potentially an effective functional food material against\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/jmf.2022.k.0133","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T12:05:20Z","timestamp":1677758720000},"page":"224-231","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Protective Effects of\n                    <i>Cudrania tricuspidata<\/i>\n                    Against\n                    <i>Helicobacter pylori<\/i>\n                    -Induced Inflammation in C57BL\/6 Mice"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-0132","authenticated-orcid":false,"given":"Jeong Yoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, University of Suwon, Hwasung, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Gu","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, University of Suwon, Hwasung, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yejin","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, University of Suwon, Hwasung, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"R&amp;BD Center, Hy Co., Ltd., Yongin, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Dong","family":"Park","sequence":"additional","affiliation":[{"name":"R&amp;BD Center, Hy Co., Ltd., Yongin, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Jung","family":"Shim","sequence":"additional","affiliation":[{"name":"R&amp;BD Center, Hy Co., Ltd., Yongin, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Lyoul","family":"Lee","sequence":"additional","affiliation":[{"name":"R&amp;BD Center, Hy Co., Ltd., Yongin, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, University of Suwon, Hwasung, South 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