{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:26:39Z","timestamp":1781529999571,"version":"3.54.1"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n                    Antihyperglycemic action of scopoletin needs to be validated before considering it for clinical trials. The present study explored antihyperglycemic action of scopoletin in high-fructose high-fat diet (HFHFD)\u2013induced diabetes in rats. The animal study was performed using 48 rats, 6 in each group. HFHFD was administered for model induction for 74 days. Rats in Group I (normal control [NC]) and group II (experimental control [EC]) received normal saline and HFHFD, respectively, throughout the study. Groups III, IV, V, and VI received oral scopoletin (1\u2009mg\/kg [low dose, LD], 5\u2009mg\/kg [medium dose, MD], 10\u2009mg\/kg [high dose, HD]), and metformin (250\u2009mg\/kg; positive control [PC] for efficacy), respectively, once daily from day 60 to 74, in addition to HFHFD. Group VII (10\u2009mg\/kg oral scopoletin safety group) and VIII (0.1\u2009mg\/kg oral warfarin; PC for safety) were separately used for bleeding time-clotting time (BTCT) assessment on days 60, 68, and 74. Groups I, VII, and VIII rats were studied for safety assessment. Later, animals were sacrificed for histological examination. Scopoletin-treated groups showed a significant decline in glucose levels, especially in the MD (5.18\u2009\u00b1\u20090.12) and HD group (5.271\u2009\u00b1\u20090.11) in comparison to the EC (6.37\u2009\u00b1\u20090.05) on day 74 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Two weeks after scopoletin treatment,\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -cell function significantly improved (53.073\u2009\u00b1\u20094.67) in the MD group versus 29.323\u2009\u00b1\u20098.505 in the NC group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). A statistically significant difference was observed when the MD group (53.07\u2009\u00b1\u20094.67) was compared to the metformin-treated group (24.80\u2009\u00b1\u20093.24;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). The safety assessment in the form of BTCT findings did not observe a difference among groups I, VII, and VIII (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&gt;\u2009.05). The study showed that scopoletin dose-independently reversed insulin resistance. Consequently, scopoletin can be a potential candidate for antidiabetic drug development.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2022.k.0153","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T14:33:01Z","timestamp":1679063581000},"page":"270-274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Scopoletin Improves Glucose Homeostasis in the High-Fructose High-Fat Diet\u2013Induced Diabetes Model in Wistar Rats"],"prefix":"10.1177","volume":"26","author":[{"given":"Gurpreet Kaur","family":"Batra","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobhit","family":"Bhansali","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-2796","authenticated-orcid":false,"given":"Amol N.","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2020.06.011"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.132156"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080020"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13004"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00006"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/2156587216671392"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00171"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.05.004"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(14)60240-9"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1265219"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/787138"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-018-3432-7"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S257919"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2021.1928716"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72694-0"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2022.K.0153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2022.K.0153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2022.K.0153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:30:52Z","timestamp":1777645852000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2022.K.0153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1089\/jmf.2022.K.0153"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2022.k.0153","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]}}}