{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:37:59Z","timestamp":1791549479869,"version":"4.3.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>\n                    Given the importance of discovering plant species from the Brazilian Cerrado biome with anticancer potential, this study evaluated the antitumor activity of two extracts of\n                    <jats:italic toggle=\"yes\">Campomanesi adamantium<\/jats:italic>\n                    fruits in\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    models of melanoma lung metastasis. Pulp and peel extracts (DEGPU and DEGPE, respectively) were extracted from fresh fruit using dichloromethane as a solvent. As cytotoxicity parameter, concentration values that inhibited 50% cell growth (GI\n                    <jats:sub>50<\/jats:sub>\n                    ), total growth inhibition (TGI), and selectivity index (SI) were established. The melanoma lung metastasis model was obtained by injecting 5 \u00d7 10\n                    <jats:sup>5<\/jats:sup>\n                    \/50 \u03bcL B16-F10 cells via the tail vein of mice, which received treatment on the 15th day. Metastatic lungs were collected for fluorescence analysis with the IR-780 marker and also macro- and microscopic assessment.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    analyses showed that DEGPU was active in K562 (GI\n                    <jats:sub>50<\/jats:sub>\n                    32.99; TGI 47.93) and U-251 (GI\n                    <jats:sub>50<\/jats:sub>\n                    32.10; TGI 249.92), whereas DEGPE showed better cytotoxicity results for all tumor cell lines, but was more efficient in K562 (GI\n                    <jats:sub>50<\/jats:sub>\n                    27.42; TGI 40.20) and U-251 (GI\n                    <jats:sub>50<\/jats:sub>\n                    4.89; TGI 12.77). Both showed a cytocidal effect on B16F10 at the highest concentration tested, with approximately 25% (DEGPU) and 88% (DEGPE) of cell death.\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    analyzes showed that both extracts showed significant activity in metastatic lung. Fluorescence images showed differences in intensity between groups owing to greater tumor involvement. Macro- and microscopic images showed that treatments with extracts limited tumor growth and prevented proliferation. The extracts tested have promising activity, thus requiring further research on their active compounds.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2023.0028","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T10:42:35Z","timestamp":1714646555000},"page":"857-865","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["New Evidence on the Antiproliferative Activity of\n                    <i>Campomanesia Adamantium<\/i>\n                    (Cambess.) O. Berg Extracts in Melanoma Lung Metastasis"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-4877","authenticated-orcid":false,"given":"Evelyn de Andrade","family":"Salom\u00e3o","sequence":"first","affiliation":[{"name":"Experimental Disease Models Multi-user Laboratory, Medical School (FAMED), Graduate Program in Health and Development in Central-West Region, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valter Arag\u00e3o do","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Experimental Disease Models Multi-user Laboratory, Medical School (FAMED), Graduate Program in Health and Development in Central-West Region, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iandara Schettert","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"Aiko Hiane","sequence":"additional","affiliation":[{"name":"Physical Chemical Food Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (FACFAN), Graduate Program in Health and Development in Central-West Region, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ligia","family":"Rodrigues Macedo","sequence":"additional","affiliation":[{"name":"Protein Purification Laboratory and Their Biological Functions, School of Pharmaceutical Sciences, Foods and Nutrition (FACFAN), Graduate Program in Health and Development in Central-West Region, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine Freitas","family":"Gielow","sequence":"additional","affiliation":[{"name":"Physical Chemical Food Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (FACFAN), Graduate Program in Health and Development in Central-West Region, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita de Cassia Avellaneda","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Experimental Disease Models Multi-user Laboratory, Medical School (FAMED), Graduate Program in Health and Development in Central-West Region, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murillo Augusto","family":"Palhares","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Bogo","sequence":"additional","affiliation":[{"name":"Molecular Biology and Cell Culture Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (FACFAN), Graduate Program in Health and Development in Central-West Region, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"MMA. 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