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Despite its efficacy and acceptability, its use is associated with adverse drug effects.\n                    <jats:italic toggle=\"yes\">Moringa oleifera<\/jats:italic>\n                    leaves are rich in phytochemical and nutritional components. It has excellent antioxidant and ethnobotanical benefits, thus popular among folk medicines and nutraceuticals. In the present study, 70% ethanol extract of moringa leaves was assessed for its\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    biochemical and histological effects against valproate-induced kidney damage. Female Sprague\u2013Dawley rats were randomly divided into four groups: Group I: control animals given physiological saline (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 8); Group II: Moringa extract-administered group (0.3 g\/kg b.w.\/day,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 8); Group III: valproate-administered animals (0.5 g\/kg b.w.\/day,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 15); and Group IV: valproate + moringa extract (given similar doses of both valproate and moringa extract,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 12) administered group. Treatments were administered orally for 15 days, the animals were fasted overnight, anesthetized, and then tissue samples harvested. In the valproate-administered experimental group, serum urea and uric acid were elevated. In the kidney tissue of the valproate rats, glutathione was depleted, antioxidant enzyme activities (superoxide dismutase, catalase, glutathione reductase, glutathione\n                    <jats:italic toggle=\"yes\">S<\/jats:italic>\n                    -transferase, and glutathione peroxidase) disrupted, while oxidative stress biomarker, inflammatory proteins (Tumor necrosis factor-alpha and interleukin-6), histological damage scores, and the number of PCNA-positive cells were elevated.\n                    <jats:italic toggle=\"yes\">M. oleifera<\/jats:italic>\n                    attenuated all these biochemical defects through its plethora of diverse antioxidant and therapeutic properties.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2023.0091","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T07:17:11Z","timestamp":1717571831000},"page":"533-544","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Biochemical and Histological Effects of\n                    <i>Moringa oleifera<\/i>\n                    Extract against Valproate-Induced Kidney Damage"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-481X","authenticated-orcid":false,"given":"Umar Faruk","family":"Magaji","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpa\u015fa, Istanbul, T\u00fcrkiye."},{"name":"Department of Biochemistry and Molecular Biology, Federal University Birnin Kebbi, Birnin Kebbi, Nigeria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melis","family":"Coremen","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Istanbul University, Istanbul, T\u00fcrkiye."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omur","family":"Karabulut Bulan","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Istanbul University, Istanbul, T\u00fcrkiye."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Sacan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpa\u015fa, Istanbul, T\u00fcrkiye."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Refiye","family":"Yanardag","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpa\u015fa, Istanbul, T\u00fcrkiye."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"issue":"10","key":"e_1_3_6_2_2","article-title":"Valproate for acute mania","volume":"10","author":"Jochim J","year":"2019","unstructured":"Jochim J, , Rifkin-Zybutz R, , Geddes J, et al. 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