{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:44:07Z","timestamp":1777909447500,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Crataegus songarica<\/jats:italic>\n                    is a native species of Pakistan. Its fruits are locally consumed for the treatment of various cardiovascular disorders, including hypertension, heart failure, and vascular insufficiency. Despite its traditional use, data regarding its effectiveness remain unclear. Therefore, the aim of the study was to evaluate the cardioprotective effects of\n                    <jats:italic toggle=\"yes\">C. songarica<\/jats:italic>\n                    fruit extract on glucose-induced hypertensive rats. First, the aqueous-methanol extract (AMECS) was obtained and subjected to phytochemical characterization. The antioxidant and cytotoxic properties were investigated\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . Acute toxicity as well as screening for hypotensive effects was also evaluated. The cardioprotective effects were assessed in glucose-induced hypertensive rats after 21 days of treatment with AMECS (500 mg\/kg single-daily oral dose). At the conclusion of the treatments, we investigated hemodynamic and biochemical parameters as well as endothelium-dependent vascular reactivity and tissue redox state. AMECS exhibited a significant antioxidant effect\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . In addition, no evidence of acute toxicity was observed. In glucose-induced hypertensive rats, AMECS prevented the increase in systolic blood pressure, oxidative stress, endothelial dysfunction, and metabolic alterations induced by glucose. The data obtained led us to conclude that the fruit extract of\n                    <jats:italic toggle=\"yes\">C. songarica<\/jats:italic>\n                    presents a significant cardioprotective effect in glucose-induced hypertensive rats.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2023.0115","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T14:02:29Z","timestamp":1752069749000},"page":"897-908","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Crataegus songarica<\/i>\n                    Fruit Ameliorates Oxidative Stress, Hypertension, and Endothelial Dysfunction in Glucose-Induced Hypertensive Rats"],"prefix":"10.1177","volume":"28","author":[{"given":"Waqas","family":"Younis","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology, University of Lahore, Lahore, Pakistan."},{"name":"Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School-Rutgers, Newark, New Jersey, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alamgeer","family":"Alamgeer","sequence":"additional","affiliation":[{"name":"University College of Pharmacy, University of the Punjab, Lahore, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Nasir Hayat","family":"Malik","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology, University of Lahore, Lahore, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq G.","family":"Alsahli","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Al Jouf University, Sakaka, Saudi Arabia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wajiha","family":"Manzoor","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology, University of Lahore, Lahore, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Majid","sequence":"additional","affiliation":[{"name":"Faculty of Biological Sciences, Department of Pharmacology, Quaid-a-Azam University, Islamabad, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malik Zahid","family":"Imran","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Sargodha, Sargodha, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muryam Abdul","family":"Razzaq","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology, University of Lahore, Lahore, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana Anne Kaneda","family":"Garcia","sequence":"additional","affiliation":[{"name":"Master\u2019s Degree in Medicinal Plants and Herbal Medicines in Basic Health Care, Paranaense University, Umuarama, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emerson Luiz Botelho","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Master\u2019s Degree in Medicinal Plants and Herbal Medicines in Basic Health Care, Paranaense University, Umuarama, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Aparecida Macedo","family":"Marques","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Laboratory of Cardiovascular Pharmacology (LaFaC), Federal University of Grande Dourados, Dourados, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-5098","authenticated-orcid":false,"given":"Arquimedes","family":"Gasparotto Junior","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Laboratory of Cardiovascular Pharmacology (LaFaC), Federal University of Grande Dourados, Dourados, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00516.2008"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2008.0055"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008176.pub2"},{"issue":"4","key":"e_1_3_4_5_2","first-page":"358","article-title":"Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants","volume":"19","author":"Baradaran A","year":"2014","unstructured":"Baradaran A, , Nasri H, , Rafieian-Kopaei M. 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