{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:10:27Z","timestamp":1781583027949,"version":"3.54.5"},"reference-count":79,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    Constipation represents a common gastrointestinal disorder that has various adverse effects on the gastrointestinal tract. As a result, various civilizations have developed phytomedicines in order to treat and relieve its symptoms. In the current study, we evaluated the effect of\n                    <jats:italic toggle=\"yes\">Crataegus azarolus<\/jats:italic>\n                    L. leaves decoction extract (CALDE) against loperamide (LOP)-induced constipation in rats. For 3 days, treated rats were administered LOP (3 mg\/kg,\n                    <jats:italic toggle=\"yes\">b.w., p.o<\/jats:italic>\n                    .) and CALDE (50, 100, and 200 mg\/kg,\n                    <jats:italic toggle=\"yes\">b.w., p.o.<\/jats:italic>\n                    ) or yohimbine (2 mg\/kg,\n                    <jats:italic toggle=\"yes\">b.w., p.o<\/jats:italic>\n                    .). The gastric emptying test or intestinal transit time was calculated. The oxidative status was studied and evaluated using biochemical colorimetric methods. Results showed that CALDE administration improves gastric emptying and accelerates gastrointestinal transit. Pretreatment with LOP altered the defecation parameters and generated an oxidative status in healthy rats. In contrast, CALDE coadministration protected against the deregulation of intestinal motor function and frequency of defecation and significantly re-established oxidative marker levels. CALDE treatment demonstrated significant protection against experimental oxidative stress and constipation induced by LOP. Therefore, it can be considered a pharmacological drug to treat these gastrointestinal troubles.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2023.0255","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T21:23:36Z","timestamp":1742419416000},"page":"465-477","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Laxative Effect of\n                    <i>Crataegus azarolus<\/i>\n                    Leaves Decoction Extract Against Loperamide-Induced Constipation and Oxidative Stress in Rats"],"prefix":"10.1177","volume":"28","author":[{"given":"Houcem","family":"Sammari","sequence":"first","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization, Higher Institute of Biotechnology of B\u00e9ja, University of Jendouba, B\u00e9ja, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4619-6892","authenticated-orcid":false,"given":"Anouar","family":"Abidi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization, Higher Institute of Biotechnology of B\u00e9ja, University of Jendouba, B\u00e9ja, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saber","family":"Jedidi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization, Higher Institute of Biotechnology of B\u00e9ja, University of Jendouba, B\u00e9ja, Tunisia."},{"name":"National Institute of Technologies and Sciences of Kef (INTeK), University of Jendouba, Kef, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourh\u00e8ne","family":"Dhawefi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization, Higher Institute of Biotechnology of B\u00e9ja, University of Jendouba, B\u00e9ja, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hichem","family":"Sebai","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization, Higher Institute of Biotechnology of B\u00e9ja, University of Jendouba, B\u00e9ja, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.015"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03376.x"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.16994"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/548024"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301181"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31820fb914"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.227132"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008788726842"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2702.2000.00357.x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199506060-00006"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i1.69"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(25)06957-1"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2006.09.006"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)99017-1"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf60219a031"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/jfca.2000.0980"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/88.5.1269"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02290.x"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3821\/2\/2224-6614.2748"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf000523q"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.1940177"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0023-6438(95)80008-5"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13858"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1993.tb01495.x"},{"issue":"2","key":"e_1_3_4_28_2","first-page":"286","article-title":"Action of caerulein on gastric emptying of the conscious rat","volume":"246","author":"Scarpignato C","year":"1980","unstructured":"Scarpignato C, , Capovilla T, , Bertaccini G. 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