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In Chinese medicine, diabetes mellitus is categorized as a \u201cthirst-quenching\u201d condition. Currently, the clinical treatment of diabetes mellitus relies mainly on Western medications, which often target the symptoms rather than alter the cause of the disease, and can cause certain side effects and drug resistance. In comparison, the polysaccharides of Chinese medicines from the same source of food and medicine have become an emerging choice for the prevention and treatment of diabetes due to their wide sources, high safety, and low side effects. To reveal the mechanisms of the polysaccharides of traditional Chinese medicine (TCM) in the prevention and treatment of diabetes mellitus, the CiteSpace visualization software was used to conduct extensive literature searches through Chinese and international databases, such as PubMed, Medline, and China National Knowledge Infrastructure. Through literature volume analysis, keyword co-occurrence, cluster analysis, and trend highlighting, we found that the main mechanisms of TCM polysaccharides in the prevention and treatment of diabetes include regulating intestinal flora, improving insulin resistance, alleviating oxidative stress, adjusting lipid metabolism imbalance, and inhibiting inflammatory responses. Furthermore, this study systematically summarizes the mechanism of \u201cusing sugar to reduce sugar\u201d to provide innovative ideas for the development of health products for the treatment of diabetes using the polysaccharides of Chinese medicinal herbs.<\/jats:p>","DOI":"10.1089\/jmf.2023.k.0093","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T05:56:20Z","timestamp":1716357380000},"page":"693-703","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Primary Mechanisms of Drug\u2013Food Homologous Traditional Chinese Medicine Polysaccharides in the Prevention and Treatment of Diabetes"],"prefix":"10.1177","volume":"27","author":[{"given":"Mengjie","family":"Wang","sequence":"first","affiliation":[{"name":"Sichuan Academy of Chinese Medicine Sciences, Chengdu, China."},{"name":"School of Food and Bioengineering, Chengdu University, Chengdu, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siye","family":"Yang","sequence":"additional","affiliation":[{"name":"Translational Chinese Medicine Key Laboratory of Sichuan Province, Chengdu, China."},{"name":"Sichuan Institute for Translational Chinese Medicine, Chengdu, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wei","sequence":"additional","affiliation":[{"name":"Sichuan Academy of Chinese Medicine Sciences, Chengdu, China."},{"name":"Translational Chinese Medicine Key Laboratory of Sichuan Province, Chengdu, China."},{"name":"Sichuan Institute for Translational Chinese Medicine, Chengdu, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026725"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2016.05.003"},{"issue":"09","key":"e_1_3_3_6_2","first-page":"1057","article-title":"The applications and research progresses of polysaccharide drugs","volume":"23","author":"Shi XL","year":"2014","unstructured":"Shi XL, , Yao CX, , Lin X, et al. 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