{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:00:27Z","timestamp":1778799627197,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                    Inflammatory bowel disease, a disease featured by intestinal epithelial barrier destruction and dysfunction, has been a constant threat to animal health. The primary objective of this research was to assess the impact of the extract derived from lotus leaves (LLE) on lipopolysaccharide (LPS) induced damage to the intestines in mice, as well as to investigate the fundamental mechanism involved. The LLE was prepared using ultrasonic extraction in this experiment, and the LLE total flavonoid content was 117.02\u2009\u00b1\u200910.73\u2009mg\/g. The LLE had strong antioxidant activity\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    , as assessed by 2, 2-diphenyl-1-picrylhydrazyl, ferric reducing antioxidant power, and 2,2\u2032-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) methods. In the\n                    <jats:italic toggle=\"yes\">vivo<\/jats:italic>\n                    experiment, different doses of LLE (50, 100, and 200\u2009mg\/kg) were administered for 2 weeks before LPS treatment in mice. The results revealed that LLE alleviates intestinal tissue damage in LPS-induced mice. In the jejunum tissue, LLE significantly upregulated mRNA and protein expression levels of tight junction proteins, such as ZO-1,\n                    <jats:italic toggle=\"yes\">occludin<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">claudin-1<\/jats:italic>\n                    , and decreased the contents of the inflammatory cytokines, interleukin (IL)-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    , IL-6, and tumor necrosis factor-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    . Furthermore, the malondialdehyde and lactate dehydrogenase contents increased by LPS in the liver were significantly reduced after administration of LLE, and the total antioxidant capacity, superoxide dismutase, and reduced glutathione decreased by LPS were remarkably increased by LLE. It was found that LLE could relieve LPS-induced oxidative stress by upregulating mRNA and protein expression of\n                    <jats:italic toggle=\"yes\">Nrf2<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">HO-1<\/jats:italic>\n                    in jejunum tissue. In conclusion, LLE alleviates LPS-induced intestinal damage through regulation of the\n                    <jats:italic toggle=\"yes\">Nrf2\/HO-1<\/jats:italic>\n                    signal pathway to alleviate oxidative stress, reducing inflammatory factors and increasing the expression of tight junction proteins in mice.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2023.k.0242","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T11:57:20Z","timestamp":1711367840000},"page":"428-436","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Lotus Leaf Extract Alleviates Lipopolysaccharide-Induced Intestinal Injury in Mice by Regulating Oxidative Stress and Inflammation"],"prefix":"10.1177","volume":"27","author":[{"given":"Yue","family":"Su","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, China."},{"name":"Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialu","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, China."},{"name":"Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, 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