{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:44:37Z","timestamp":1777909477860,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                    Although hair loss contributes to various social and economic, research methods for material development are currently limited. In this study, we established a research model for developing materials for hair growth through the regulation of\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -catenin. We confirmed that 100\u2009nM tegatrabetan (TG), a\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -catenin inhibitor, decreased the proliferation of human hair follicle dermal papilla cells (HFDPCs) at 72\u2009h. In addition, TG-induced apoptosis suppressed the phosphorylation of GSK-3\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    and Akt, translocation of\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -catenin from the cytosol to the nucleus, and the expression of cyclin D1. Interestingly, TG significantly increased the G2\/M arrest in HFDPCs. Subcutaneous injection of TG suppressed hair growth and the number of hair follicles in C57BL\/6 mice. Moreover, TG inhibited the expression of cyclin D1,\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -catenin, keratin 14, and Ki67. These results suggest that TG-induced inhibition of hair growth can be a promising model for developing new materials for enhancing\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -catenin-mediated hair growth.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2023.k.0258","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T12:00:18Z","timestamp":1709208018000},"page":"449-459","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>\n                    Models for the Development of Hair Growth Materials By Regulating the\n                    <i>\u03b2<\/i>\n                    -Catenin Signaling Pathways"],"prefix":"10.1177","volume":"27","author":[{"given":"Min Jeong","family":"Woo","sequence":"first","affiliation":[{"name":"School of Food Science and Biotechnology, Kyungpook National University, Daegu, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JeongIn","family":"Choi","sequence":"additional","affiliation":[{"name":"Research and Development Center, Nong Shim Co., Ltd., Seoul, Korea."},{"name":"Department of Bioindustrial Engineering, Yonsei University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha Yeong","family":"Kang","sequence":"additional","affiliation":[{"name":"School of Food Science and Biotechnology, Kyungpook National University, Daegu, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehyeon","family":"Jang","sequence":"additional","affiliation":[{"name":"School of Food Science and Biotechnology, Kyungpook National University, Daegu, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Food Science and Biotechnology, Kyungpook National University, Daegu, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SeaHyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Research and Development Center, Nong Shim Co., Ltd., Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanguine","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Bioindustrial Engineering, Yonsei University, Seoul, Korea."},{"name":"Department of Biotechnology, Yonsei University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Keun","family":"Jung","sequence":"additional","affiliation":[{"name":"School of Food Science and Biotechnology, Kyungpook National University, Daegu, Korea."},{"name":"Research Institute of Tailored Food Technology, Kyungpook National University, Daegu, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"issue":"6","key":"e_1_3_5_2_2","first-page":"371","article-title":"Hair loss: Common causes and treatment","volume":"96","author":"Phillips TG","year":"2017","unstructured":"Phillips TG, , Slomiany WP, , Allison R. 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