{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:44:38Z","timestamp":1777909478129,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    Obesity is a threat to public health and effective new medications are required. Platycodonis Radix (PR) is a traditional medicinal\/dietary plant with activities against obesity. Using mice given a diet rich in fat, the antiobesity components of PR were identified and their molecular mechanisms were clarified further in this investigation. Initially, the impacts of PR fractions on liver histology and biochemical markers were assessed. Subsequently, the degrees of lipogenic and lipolytic gene and protein expressions were determined. Oral administration of PR polysaccharides (PG) (0.80\u2009g\/kg body weight) improved liver function (alanine aminotransferase and aspartate aminotransferase) and its antioxidant activities (total superoxide dismutase, glutathione peroxidase, and malondialdehyde), as well as alleviated blood lipid (total cholesterol, total triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) values, inflammatory systemic (TNF-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    and IL-1\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    ), and histological abnormalities within the liver. Furthermore, PG administration downregulated the expression for lipogenic genes (ACC and FAS) and upregulated the expression for the lipolytic gene (PPAR\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    , LPL, CPT1, and HSL). Importantly, PG raised AMPK phosphorylation and decreased SREBP-1c protein synthesis. Thus, it is possible that PG stimulates the AMPK-LPL\/HSL path (lipolytic route) plus the AMPK-ACC\/PPAR\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    -CPT1 path (associated to\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -oxidation of fatty acids), while inhibiting the AMPK\/(SREBP-1c)-ACC\/FAS path (lipogenic route). In summary, PG has the ability to regulate lipid metabolism, and it may be useful to pharmacologically activate AMPK with PG to prevent and cure obesity.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2023.k.0265","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T15:54:36Z","timestamp":1710777276000},"page":"477-487","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Screening of Platycodonis Radix Fractions for Antiobesity Activities and Elucidation of Its Molecular Mechanisms in High-Fat Diet-Fed C57BL\/6 Mice"],"prefix":"10.1177","volume":"27","author":[{"given":"Nannan","family":"Zhi","sequence":"first","affiliation":[{"name":"Department of Food and Biopharmaceuticals, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangwei","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Food and Biopharmaceuticals, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China."},{"name":"Department of Pharmacy, Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, China."},{"name":"Department of Pharmacy, Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, China."},{"name":"Department of Pharmacy, Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei, China."},{"name":"Department of Traditional Chinese Medicine Resource, MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinrui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Food and Biopharmaceuticals, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Resource, State Key Laboratory of Dao-di Herbs, Beijng, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Food and Biopharmaceuticals, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangping","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Food and Biopharmaceuticals, College of Pharmacy, Anhui University of Chinese Medicine, 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