{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:44:38Z","timestamp":1777909478429,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                    The primary inflammatory process in atherosclerosis, a major contributor to cardiovascular disease, begins with monocyte adhering to vascular endothelial cells.\n                    <jats:italic toggle=\"yes\">Actinidia arguta<\/jats:italic>\n                    (kiwiberry) is an edible fruit that contains various bioactive components. While\n                    <jats:italic toggle=\"yes\">A. arguta<\/jats:italic>\n                    extract (AAE) has been recognized for its anti-inflammatory characteristics, its specific inhibitory effect on early atherogenic events has not been clarified. We used tumor necrosis factor-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    (TNF-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    )\u2013stimulated human umbilical vein endothelial cells (HUVECs) for an\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    model. AAE effectively hindered the attachment of THP-1 monocytes and reduced the expression of vascular cell adhesion molecule-1 (VCAM-1) in HUVECs. Transcriptome analysis revealed that AAE treatment upregulated phosphatase and tensin homolog (PTEN), subsequently inhibiting phosphorylation of AKT and glycogen synthase kinase 3\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    (GSK3\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    ) in HUVECs. AAE further hindered phosphorylation of AKT downstream of the nuclear factor kappa B (NF-\n                    <jats:italic toggle=\"yes\">\u03ba<\/jats:italic>\n                    B) signaling pathway, leading to suppression of target gene expression. Oral administration of AAE suppressed TNF-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    \u2013stimulated VCAM-1 expression, monocyte-derived macrophage infiltration, and proinflammatory cytokine expression in C57BL\/6 mouse aortas.\n                    <jats:italic toggle=\"yes\">Myo<\/jats:italic>\n                    -inositol, identified as the major compound in AAE, played a key role in suppressing THP-1 monocyte adhesion in HUVECs. These findings suggest that AAE could serve as a nutraceutical for preventing atherosclerosis by inhibiting its initial pathogenesis.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2023.k.0326","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T12:54:55Z","timestamp":1713963295000},"page":"419-427","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Actinidia arguta<\/i>\n                    Extract Containing\n                    <i>Myo<\/i>\n                    -Inositol Suppresses TNF-\n                    <i>\u03b1<\/i>\n                    -Induced VCAM-1 Expression and Monocyte Adhesion to Endothelial Cells via Inhibition of the PTEN\/Akt\/GSK-3\n                    <i>\u03b2<\/i>\n                    and NF-\n                    <i>\u03ba<\/i>\n                    B Signaling Pathways"],"prefix":"10.1177","volume":"27","author":[{"given":"Jangho","family":"Lee","sequence":"first","affiliation":[{"name":"Divisions of Functional Food Research, Korea Food Research Institute, Wanju-gun, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon","family":"Park","sequence":"additional","affiliation":[{"name":"Divisions of Strategic Food Technology Research, Korea Food Research Institute, Wanju-gun, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8691-8573","authenticated-orcid":false,"given":"Kyung-Mo","family":"Song","sequence":"additional","affiliation":[{"name":"Divisions of Strategic Food Technology Research, Korea Food Research Institute, Wanju-gun, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Geon","family":"Lee","sequence":"additional","affiliation":[{"name":"Divisions of Functional Food Research, Korea Food Research Institute, Wanju-gun, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Kyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Divisions of Functional Food Research, Korea Food Research Institute, Wanju-gun, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.103"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/35025203"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvasa.2015.08.002"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.05.037"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66843"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000143933.20616.1b"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2012"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11871"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-017-0637-y"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03124.x"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700658"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.08.019"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2016.09.010"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2020.03.003"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/c7fo00178a"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/43466"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-04-0299"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.07.061"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.05.012"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3520"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.11.008"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.03.035"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.03.011"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.05.011"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.01.008"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-15-0254"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509779103"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.274.1.C58"}],"container-title":["Journal 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