{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:44:44Z","timestamp":1777909484109,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Acorus gramineus<\/jats:italic>\n                    has a number of beneficial effects, including protective effects against age-related disorders. In this study, the effects of\n                    <jats:italic toggle=\"yes\">A. gramineus<\/jats:italic>\n                    on testosterone production and andropause symptoms were evaluated. We first treated TM3 mouse Leydig cells, responsible for testosterone production, with\n                    <jats:italic toggle=\"yes\">A. gramineus<\/jats:italic>\n                    aqueous extract at different concentrations. In TM3 cells, the testosterone concentration increased in a concentration-dependent manner compared with those in the control. In addition, at 400 \u03bcg\/mL extract, the mRNA expression level of the steroidogenic enzyme\n                    <jats:italic toggle=\"yes\">CYP11A1<\/jats:italic>\n                    was increased. Subsequently, 23-week-old Sprague\u2013Dawley (SD) rats exhibiting an age-related reduction in serum testosterone (approximately 80% lower than that in 7-week-old SD rats) were administered\n                    <jats:italic toggle=\"yes\">A. gramineus<\/jats:italic>\n                    aqueous extract for 8 weeks. Serum total testosterone and free testosterone levels were higher and serum estradiol, prostate-specific antigen levels, and total cholesterol levels were lower in the AG50 group (\n                    <jats:italic toggle=\"yes\">A. gramineus<\/jats:italic>\n                    aqueous extract 50 mg\/kg of body weight\/day) than in the OLD (control group). The AG50 group also showed significant elevations in sperm count, grip strength, and mRNA expression of\n                    <jats:italic toggle=\"yes\">StAR<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">CYP11A1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">17\u03b2-HSD<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">CYP17A1<\/jats:italic>\n                    compared with those in the OLD group. In conclusion,\n                    <jats:italic toggle=\"yes\">A. gramineus<\/jats:italic>\n                    aqueous extract facilitated steroidogenesis in Leydig cells, elevated testosterone levels, lowered serum estradiol and total cholesterol levels, and increased muscle strength and sperm count, thus alleviating the symptoms of andropause. These findings suggest that\n                    <jats:italic toggle=\"yes\">A. gramineus<\/jats:italic>\n                    aqueous extract is a potentially effective therapeutic agent against various symptoms associated with andropause.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2023.k.0332","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T04:41:07Z","timestamp":1717389667000},"page":"740-748","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Improvement in Testosterone Production by\n                    <i>Acorus gramineus<\/i>\n                    for the Alleviation of Andropause Symptoms"],"prefix":"10.1177","volume":"27","author":[{"given":"Jeong Yoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, University of Suwon, Hwasung, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seokho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, University of Suwon, Hwasung, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, University of Suwon, Hwasung, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hum","family":"Yeon","sequence":"additional","affiliation":[{"name":"Healthcare Research Division, Huons(O) Global Ltd., Seongnam(O), South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Healthcare Research Division, Huons(O) Global Ltd., Seongnam(O), South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rak Ho","family":"Son","sequence":"additional","affiliation":[{"name":"Healthcare Research Division, Huons(O) Global Ltd., Seongnam(O), South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae Lee","family":"Park","sequence":"additional","affiliation":[{"name":"Healthcare Research Division, Huons(O) Global Ltd., Seongnam(O), South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-0132","authenticated-orcid":false,"given":"Yoo-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, University of Suwon, Hwasung, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2007-1245"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.123552"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.5114\/PM.2017.68595"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2006-1859"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S190"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/GLS068"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/BIOLRE\/IOY059"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/ER.2010-0013"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/JCEM-59-4-756"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2019.00372"},{"issue":"6","key":"e_1_3_6_12_2","first-page":"S9","article-title":"Testosterone replacement in men with andropause: An overview","volume":"6","author":"Brawer MK","year":"2004","unstructured":"Brawer MK. 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