{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:09:41Z","timestamp":1790798981362,"version":"4.1.0"},"reference-count":111,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Several studies suggest a favorable effect of 100% fruit juice (100%FJ) on cardio-metabolic risk. However, international dietary guidelines disagree on recommendations regarding fruit drink consumption, and the published European Food Safety Authority draft, based only on epidemiological data, suggested a direct relationship between 100%FJ intake and the development of type 2 diabetes mellitus (T2DM) and gout. Thus, we performed a systematic review of both randomized controlled trials (RCT) and prospective studies that assessed the relationship between 100%FJ intake, uric acid metabolism, and glucose profile. Concerning previous meta-analyses, no new prospective studies were identified for the evaluation of T2DM, and no studies were identified for the assessment of gout risk in the general population; conversely, 3 studies were detected for the assessment of gestational diabetes risk. Moreover, new RCTs were detected and included in an updated meta-analysis on glucose profile and uric acid. 100%FJ intake was associated with a decrease in uric acid, and neutral associations were found for different markers of glucose metabolism and the risk of gestational diabetes. In summary, this meta-analysis confirmed that there was no difference between 100%FJ intake and the comparator on glucose metabolism. It also showed that 100%FJ intake resulted in lower levels of uric acid than the comparator. In addition, the analysis indicated a neutral effect of 100%FJ on gestational diabetes. Finally, the systematic review confirmed the neutral effect of 100%FJ on T2DM and suggested the need for further studies to evaluate the risk of gout.<\/jats:p>","DOI":"10.1089\/jmf.2024.0139","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T11:57:25Z","timestamp":1749815845000},"page":"743-756","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["100% Fruit Juice Intake, Glucose Profile, and Uric Acid: A Systematic Review"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1782-0211","authenticated-orcid":false,"given":"Lanfranco","family":"D\u2019Elia","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University of Naples Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aquilino Flavio","family":"Zarrella","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University of Naples Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria Libera","family":"Pizzulo","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University of Naples Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Attanasio","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University of Naples Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Rendina","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University of Naples Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Sievenpiper","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine, Department of Nutritional Sciences, University of Toronto, Toronto, Canada."},{"name":"Temerty Faculty of Medicine, Department of Medicine, University of Toronto, Toronto, Canada."},{"name":"Division of Endocrinology &amp; Metabolism, Department of Medicine, St. Michael\u2019s Hospital, Toronto, Canada."},{"name":"Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael\u2019s Hospital, Toronto, Canada."},{"name":"Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124845"},{"key":"e_1_3_5_3_2","unstructured":"Available from: http:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2012:115:0001:0011:EN:PD"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-020-02426-7"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017728"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093471"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxab144"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024171"},{"key":"e_1_3_5_9_2","volume-title":"2015\u20132020 Dietary Guidelines for Americans","author":"Department of Health and Human Services and US Department of Agriculture","year":"2015","unstructured":"Department of Health and Human Services and US Department of Agriculture. 2015\u20132020 Dietary Guidelines for Americans. 8th ed. US Government Printing Office: Washington, DC; 2015.","edition":"8"},{"key":"e_1_3_5_10_2","unstructured":"Available from: http:\/\/www.heart.org\/HEARTORG\/HealthyLiving\/HealthyEating\/HealthyDietGoals\/Suggested-Servings-from-Each-Food-Group_UCM_318186_Article.jsp#.WAYU8uCLRm9"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/nbu.12211"},{"key":"e_1_3_5_12_2","volume-title":"Dutch Dietary Guidelines 2015","author":"Health Council of the Netherlands","year":"2015","unstructured":"Health Council of the Netherlands. Dutch Dietary Guidelines 2015. Publication no. 2015\/24E. Health Council of the Netherlands: The Hague; 2015."},{"key":"e_1_3_5_13_2","volume-title":"Livelli di Assunzione di Riferimento di Nutrienti ed energia per la popolazione italiana \u2013 IV Revisione","author":"Societ\u00e0 Italiana di Nutrizione Umana\u2014SINU","year":"2014","unstructured":"Societ\u00e0 Italiana di Nutrizione Umana\u2014SINU. Livelli di Assunzione di Riferimento di Nutrienti ed energia per la popolazione italiana \u2013 IV Revisione. SICS Ed.; 2014."},{"key":"e_1_3_5_14_2","unstructured":"EFSA (European Food Safety Authority. Draft Scientific Opinion on the Tolerable Upper Intake Level for Dietary Sugars. 2021. Available from: https:\/\/efsa.onlinelibrary.wiley.com\/doi\/epdf\/10.2903\/j.efsa.2022.7074 [Last accessed: October25 2022]."},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S003"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_3_5_18_2","unstructured":"Higgins J Morgan R Rooney A et al.; ROBINS-E Development Group. Risk Of Bias In Non-randomized Studies \u2013 of Exposure (ROBINS-E). Launch version 20 June 2023. Available from: https:\/\/www.riskofbias.info\/welcome\/robins-e-tool"},{"key":"e_1_3_5_19_2","unstructured":"Higgins JPT Thomas J Chandler J Cumpston M Li T Page MJ Welch VA. eds. Cochrane Handbook for Systematic Reviews of Interventions Version 6.3. (Updated February 2022). Cochrane. Available from: www.training.cochrane.org\/handbook [Last accessed: March31 2022]."},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_3_5_21_2","unstructured":"Sch\u00fcnemann H Bro\u017cek J Guyatt G et al. GRADE Handbook. Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach. 2013. Available from: https:\/\/gdt.gradepro.org\/app\/handbook\/handbook.html [Last accessed: March31 2022]."},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr265"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-018-0483-0"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4002"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2017.08.031"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.050997"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3572-1"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.14.1487"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxz340"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2105"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.08.033"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114518001277"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2008.0300"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.124701"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2010.06.016"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2011.02.003"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.031088"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602309"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1039\/c8fo00468d"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29905"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.004242"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000165168.68054.f8"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1159\/000330116"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2007.12.001"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2009.10719789"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-010-0092-0"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.7977"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf300277g"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2016.09.005"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/07448481.2021.2024550"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-017-0605-6"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.004945"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.203190"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00800306"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2012.11.002"},{"issue":"4","key":"e_1_3_5_58_2","first-page":"355","article-title":"The effects of cranberry juice on serum glucose, apoB, apoA-I, Lp(a), and Paraoxonase-1 activity in type 2 diabetic male patients","volume":"17","author":"Shidfar F","year":"2012","unstructured":"Shidfar F, , Heydari I, , Hajimiresmaiel SJ, et al. The effects of cranberry juice on serum glucose, apoB, apoA-I, Lp(a), and Paraoxonase-1 activity in type 2 diabetic male patients. J Res Med Sci, 2012; 17(4):355\u2013360.","journal-title":"J Res Med Sci"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt176"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-8-8"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1039\/c6fo00039h"},{"issue":"3","key":"e_1_3_5_62_2","first-page":"215","article-title":"Effects of pomegranate juice consumption on inflammatory markers in patients with type 2 diabetes: A randomized, placebo-controlled trial","volume":"19","author":"Sohrab G","year":"2014","unstructured":"Sohrab G, , Nasrollahzadeh J, , Zand H, et al. Effects of pomegranate juice consumption on inflammatory markers in patients with type 2 diabetes: A randomized, placebo-controlled trial. J Res Med Sci, 2014; 19(3):215\u2013220.","journal-title":"J Res Med Sci"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.3402\/fnr.v59.28551"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.05.026"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7038789"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2012.10"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2019.0240"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19095317"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13072208"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1638"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39449.819271.BE"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095323"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2017.63"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01073-0"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ19-0445"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1239"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2018.01.004"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12696"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14142846"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.161968"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114519000084"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1175022"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.23.2792"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2879"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(80)90074-8"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.161570"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-032240"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14224785"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-023-00855-8"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010129"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14193986"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102513"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10040459"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1177\/0260106020944299"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7085268"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-019-0235-6"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j2376"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-023-00602-4"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2022.01.028"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500327"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.10.199"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.04.017"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.1551"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00442-4"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007685909018"},{"key":"e_1_3_5_106_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21105"},{"key":"e_1_3_5_107_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf505297t"},{"key":"e_1_3_5_108_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5001"},{"key":"e_1_3_5_109_2","unstructured":"Available from: https:\/\/aijn.eu\/files\/attachments\/.598\/2018_Liquid_Fruit_Market_Report.pdf"},{"key":"e_1_3_5_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_3_5_111_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw319"},{"key":"e_1_3_5_112_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40795-020-00347-6"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2024.0139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2024.0139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2024.0139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:32:00Z","timestamp":1777645920000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2024.0139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":111,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1089\/jmf.2024.0139"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2024.0139","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]}}}