{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:45:07Z","timestamp":1777909507497,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>\n                    Probiotics are well-known to be directly or indirectly involved in the host immune system. In this study, we analyzed the immune-boosting effects of lactic acid bacteria, including\n                    <jats:italic toggle=\"yes\">Limosilactobacillus<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Lactococcus<\/jats:italic>\n                    , in immunocompetent C57BL\/6J mice. Three different lactic acid bacteria strains were orally administered to C57BL\/6J mice for 8 weeks. Then, liver, spleen, and whole blood were harvested after sacrificing the animals. There were no significant changes in whole-body weight, weight of organs, or complete blood cell count by oral administration of lactic acid bacteria. The frequencies of CD3\n                    <jats:sup>+<\/jats:sup>\n                    , CD4\n                    <jats:sup>+<\/jats:sup>\n                    , and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells were significantly increased in the\n                    <jats:italic toggle=\"yes\">Limosilactobacillus reuteri<\/jats:italic>\n                    MG5462 group compared to control. The frequency of NK1.1\n                    <jats:sup>+<\/jats:sup>\n                    cells was significantly increased in the\n                    <jats:italic toggle=\"yes\">Lactococcus lactis<\/jats:italic>\n                    MG5474 group compared to control. On the other hand, splenocyte proliferations and natural killer cytotoxicity did not differ between groups. In addition, the MG5462 group had a significant increase in the production of TNF-\u03b1 compared to the control, which is consistent with the upregulation of T cells in the MG5462 group. Therefore,\n                    <jats:italic toggle=\"yes\">Limosilactobacillus reuteri<\/jats:italic>\n                    could be a functional food additive to boost immunity by positively affecting T cell populations.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2024.k.0085","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T04:05:12Z","timestamp":1719374712000},"page":"713-719","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Immune Boosting Effect of\n                    <i>Limosilactobacillus Reuteri<\/i>\n                    in Immunocompetent C57BL\/6J Mice"],"prefix":"10.1177","volume":"27","author":[{"given":"Hyunna","family":"Jung","sequence":"first","affiliation":[{"name":"College of Pharmacy, Duksung Women\u2019s University, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwan Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Duksung Women\u2019s University, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyojeung","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-5742","authenticated-orcid":false,"given":"Hyosun","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Duksung Women\u2019s University, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17049"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12124150"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0437-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11020528"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021526"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2023.101724"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.01.012"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.700217"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-022-01199-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15041038"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10112247"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010184"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00268"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.79430"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032696"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-8165-1.00023-X"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2307\/65983"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052719"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2020.1775643"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2024.k.0085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2024.k.0085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2024.k.0085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:32:16Z","timestamp":1777645936000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2024.k.0085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1089\/jmf.2024.k.0085"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2024.k.0085","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]}}}