{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:17:22Z","timestamp":1792480642326,"version":"4.5.0"},"reference-count":63,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>\n                    Gastritis and gastric ulcers are common gastric diseases that are caused by infection, drugs, alcohol consumption, or stress. These conditions lead to increased inflammatory cytokines and recruitment of leukocytes, which damage the stomach mucosa and exacerbate disease severity.\n                    <jats:italic toggle=\"yes\">Sicyos angulatus<\/jats:italic>\n                    (SA), an annual vine in the\n                    <jats:italic toggle=\"yes\">Cucurbitaceae<\/jats:italic>\n                    family, is known to have an anti-inflammatory effect, but its efficacy for preventing gastritis and gastric ulcers has not yet been evaluated. In the present study, we investigated the gastroprotective effect of SA using a hydrochloric acid\/ethanol-induced gastric mucosal injury mouse model and lipopolysaccharide (LPS)-stimulated KATO III cells. Macroscopic analysis revealed a reduction in gastric ulcer area. Similarly, histopathological analysis showed a dose-dependent decrease in gastric mucosal injury, with significant improvement at 750 mg\/kg of SA treatment. Gene expressions of inflammatory cytokines, chemokines, and adhesion molecule were reduced in the SA-administered group. Immunohistochemical staining indicated that SA significantly decreased neutrophil infiltration in the lamina propria and epithelium of the stomach. Kaempferol, a major bioactive flavonoid of SA, also improved gastric injury by reducing macroscopic and microscopic lesions, inflammatory mediator gene expression, and neutrophil infiltration. Furthermore, both SA and kaempferol downregulated LPS-mediated increases in inflammatory cytokines and chemokines following inhibition of p38 and c-Jun N-terminal kinase (JNK) phosphorylation in KATO III cells. These results suggest that SA can ameliorate gastric mucosal injury by inhibiting the recruitment of inflammatory cells, particularly neutrophils, and by suppressing p38 and JNK phosphorylation.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2024.k.0091","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T14:45:06Z","timestamp":1727275506000},"page":"1219-1230","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["The Gastroprotective Effect of\n                    <i>Sicyos angulatus<\/i>\n                    Against Hydrochloric Acid\/Ethanol-Induced Acute Gastritis and Gastric Ulcer in Mice"],"prefix":"10.1177","volume":"27","author":[{"given":"Hye-Rin","family":"Kim","sequence":"first","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."},{"name":"Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeo, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Chan","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."},{"name":"Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeo, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Jung","family":"Kang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hyeon","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Keun","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Bok","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Jeong","family":"Seo","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Ran","family":"Noh","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0682-2238","authenticated-orcid":false,"given":"Yong-Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."},{"name":"Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeo, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea."},{"name":"Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeo, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2018.5"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809099130"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.798421"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.12759"},{"key":"e_1_3_5_6_2","first-page":"56","article-title":"Antacid therapy\u2013changes in mineral metabolism","volume":"75","author":"Herzog P","year":"1982","unstructured":"Herzog P, , Holterm\u00fcller K. 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