{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:47:36Z","timestamp":1790898456713,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>\n                    Skeletal muscle atrophy refers to the loss of muscle strength and mass due to decreased protein synthesis or increased protein degradation. Various conditions can cause muscle atrophy, including aging, heart disease, chronic illness, obstructive pulmonary disease, kidney failure, diabetes, AIDS, cancer, sepsis, and steroid use. Various natural materials have been studied for the prevention of muscle atrophy. In this study, we found that extracts from the sprouts of purple wheat, Arriheuk, prevented muscle atrophy\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . Arriheuk wheat sprouts extract inhibited the expression of muscle protein breakdown factors, which were increased by dexamethasone, and improved muscle strength. In C2C12 myotubes, Arriheuk wheat sprout extract (ARE) protected against dexamethasone-induced muscle atrophy by potentiating Akt\/mammalian target of rapamycin and AMP-activated protein kinase (AMPK)\/forkhead box O3 (AMPK\/Foxo3) signaling and inhibiting the expression of Atrogin-1, muscle RING-finger protein-1 (MuRF1), and Myostatin. In addition, the administration of ARE in an animal model of muscle atrophy induced by dexamethasone prevented myocardial and muscle strength loss by regulating the expression of muscle atrophy-related factors by affecting AMPK\/Foxo3 signaling. Taken together, these results suggest that Arriheuk wheat sprouts extract effectively alleviates muscle atrophy by regulating the synthesis and breakdown of muscle proteins.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2024.k.0104","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:17:29Z","timestamp":1728559049000},"page":"1201-1209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Suppressive Effects of Arriheuk Wheat Sprout Extract on Muscle Atrophy in Dexamethasone-Induced C2C12 Myotubes and a Mouse Model"],"prefix":"10.1177","volume":"27","author":[{"given":"Hyun Sun","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Food and Biotechnology Korea University, Sejong 30019, Korea."},{"name":"BK21 FOUR Research Education Team for Omics-Based Bio-Health in Food Industry, Korea University, Sejong 30019, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Biotechnology Korea University, Sejong 30019, Korea."},{"name":"Institute of Natural Sciences, Korea University, Sejong 30019, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Amaya-Quiroz","sequence":"additional","affiliation":[{"name":"Department of Food Science and Agricultural Chemistry, Macdonald Campus, McGill University, 21111 Lakeshore, Ste Anne de Bellevue, QC H9X 3V9, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeock","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Food and Biotechnology Korea University, Sejong 30019, Korea."},{"name":"Department of Food Regulatory Science, Korea University, Sejong 30019, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bok 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