{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:45:07Z","timestamp":1777909507524,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>\n                    Menopausal depression, often associated with hormonal fluctuations such as decreased estrogen levels, imposes significant mental health burdens. Despite the antidepressant biological properties of standardized rice bran supplement (RBS), its impact on menopausal depression and underlying mechanisms remains largely unexplored. In this study, we investigated the antidepressant effects of RBS in a mouse model of estrogen deficiency\u2013induced depression. Ovariectomized (OVX) mice received oral doses of RBS (250 and 1000 mg\/kg) and 17\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    estradiol over a 20-week period. RBS administration resulted in decreased immobility time in the tail suspension and forced swim tests, along with increased locomotor activity in the open field test. Furthermore, RBS enhanced nitric oxide production and neuronal nitric oxide synthase (nNOS) expression in the hippocampi of OVX mice. Additionally, RBS administration phosphorylated extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB), and tropomyosin receptor kinase B and increased the protein expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. These findings suggest that RBS alleviated depressive behaviors in OVX mice by augmenting hippocampal nNOS expression and activating the ERK-CREB-BDNF signaling pathway. Therefore, based on these results, we propose that RBS is a promising agent to treat menopausal depression, a challenging condition.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2024.k.0112","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T18:37:55Z","timestamp":1723142275000},"page":"879-886","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ameliorating Effect of Standardized Rice Bran Supplement on Depressive-Like Behaviors in Ovariectomized Mice"],"prefix":"10.1177","volume":"27","author":[{"given":"Minji","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Wanju, Republic of Korea."},{"name":"Department of Food Biotechnology, University of Science &amp; Technology, Daejeon, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suengmok","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology\/Institute of Food Science, Pukyong National University, Busan, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Wanju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Young","family":"Um","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Wanju, Republic of Korea."},{"name":"Department of Food Biotechnology, University of Science &amp; 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