{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:45:13Z","timestamp":1777909513501,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    Inflammation is a crucial response to harmful stimuli, but its chronic activation contributes to various diseases, including inflammatory bowel disease, osteoarthritis, and neurological disorders. While nonsteroidal anti-inflammatory drugs are widely used as anti-inflammation drugs, their extended usage often results in severe side effects, emphasizing the need for safer alternatives. Therefore, it is of the greatest importance to identify and discover new anti-inflammatory agents that exhibit a reduced incidence of adverse side effects. This study investigates the anti-inflammatory potential of methanol extracts from eight native Vietnamese plant species. These extracts were screened for their ability to inhibit nitric oxide production and pro-inflammatory cytokine expression in lipopolysaccharides-stimulated RAW264.7 macrophages. Among the tested extracts, those derived from\n                    <jats:italic toggle=\"yes\">Huberantha luensis<\/jats:italic>\n                    (Pierre) Chaowasku and\n                    <jats:italic toggle=\"yes\">Ancistrocladus tectorius<\/jats:italic>\n                    (Lour.) Merr. demonstrated notable reductions in NO, TNF-\u03b1, interleukin (IL)-1\u03b2, and IL-6 levels. Further analysis revealed that these extracts are abundant in polyphenols and flavonoids, compounds recognized for their anti-inflammatory effects. Furthermore, these extracts exerted their effects by inhibiting the kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinase signaling pathways, as evidenced by reduced phosphorylation of the proteins. These results suggest that the methanol extracts obtained from\n                    <jats:italic toggle=\"yes\">H. luensis<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">A. tectorius<\/jats:italic>\n                    possess considerable potential in paving the way towards the innovative development of new therapeutic approaches aimed at alleviating chronic inflammation.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2024.k.0276","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T05:14:22Z","timestamp":1745212462000},"page":"448-454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-Inflammatory Effects of\n                    <i>Huberantha luensis and Ancistrocladus tectorius<\/i>\n                    Extracts Through Inhibition of Nuclear Factor-\u03baB and Mitogen-Activated Protein Kinase Pathways"],"prefix":"10.1177","volume":"28","author":[{"given":"Seong Ju","family":"Oh","sequence":"first","affiliation":[{"name":"FromBIO Inc, Yongin-si, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sun","family":"Jang","sequence":"additional","affiliation":[{"name":"Kangwon National University College of Pharmacy, Chuncheon, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Ryoung","family":"Kim","sequence":"additional","affiliation":[{"name":"FromBIO Inc, Yongin-si, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Il","family":"Kim","sequence":"additional","affiliation":[{"name":"FromBIO Inc, Yongin-si, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HyeBin","family":"Kim","sequence":"additional","affiliation":[{"name":"FromBIO Inc, Yongin-si, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YoungEun","family":"Kim","sequence":"additional","affiliation":[{"name":"FromBIO Inc, Yongin-si, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae Won","family":"Park","sequence":"additional","affiliation":[{"name":"FromBIO Inc, Yongin-si, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hi Su","family":"Jang","sequence":"additional","affiliation":[{"name":"FromBIO Inc, Yongin-si, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"The Bach","family":"Tran","sequence":"additional","affiliation":[{"name":"Vietnam Academy of Science and Technology Institute of Ecology and Biological Resources, Hanoi, Vietnam."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thu Thuy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Korea Research Institute of Bioscience &amp; Biotechnology, Biological Material Research Center, Yuseong-gu, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Kee","family":"Hong","sequence":"additional","affiliation":[{"name":"FromBIO Inc, Yongin-si, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuu066"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114512005119"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2011.06.015"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ewjm.175.4.267"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.10.005"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000058761"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.807"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.12.009"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci11837"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0429-9"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci11830"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/plants12040967"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1558-4_19"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.03.044"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.01.114"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1359-6101(02)00026-6"},{"issue":"4","key":"e_1_3_4_19_2","first-page":"353","article-title":"Analysis of serum pro-inflammatory cytokine levels after rat spinal cord ischemia\/reperfusion injury and correlation with tissue damage","volume":"19","author":"Hasturk A","year":"2009","unstructured":"Hasturk A, , Atalay B, , Calisaneller T, et al. 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