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Using an experimental rat model, we explored the impact of theophylline on respiratory parameters, including respiratory rate, tidal volume, and minute volume. Thirty-two 6-week-old male Sprague\u2013Dawley rats were randomly divided into control and experimental groups. The experimental group received a single oral dose of 100 mg\/kg theophylline. Respiratory parameters were measured at baseline (0 h) and at 0.5, 1, 2, 4, and 6 h post oral administration of theophylline using a whole-body plethysmograph. Oral theophylline administration significantly increased the respiratory rate and minute volume at all postdose time points compared with those in the control group, and peak values were observed at 0.5 h postadministration (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). In contrast, the tidal volume remained consistent across all time points, indicating that theophylline enhances respiratory efficiency primarily by increasing the frequency of breaths rather than by altering their depth. Our study demonstrated the ability of theophylline to enhance respiratory efficiency via increased breathing frequency without affecting tidal volume, thus offering insights into the clinical significance of oral theophylline in managing chronic respiratory diseases.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2025.k.0007","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T20:57:41Z","timestamp":1744405061000},"page":"947-953","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety Pharmacological Assessment of Oral Theophylline Administration on Respiratory Function in Sprague\u2013Dawley Rats"],"prefix":"10.1177","volume":"28","author":[{"given":"Sung-Hyun","family":"Cho","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Chonnam National University, Gwangju, Korea."},{"name":"Safety Evaluation Team, CentralBio Co., Ltd., Incheon, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minseo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Dankook University, Cheonan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caglar","family":"Doguer","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Tekirda\u011f Nam\u0131k Kemal University, Tekirda\u011f, T\u00fcrkiye."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miae","family":"Doo","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Kunsan National University, Gunsan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5282-531X","authenticated-orcid":false,"given":"Jung-Heun","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Dankook University, Cheonan, Korea."},{"name":"Research Center for Industrialization of Natural Neutralization, Dankook University, Yongin, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113074"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1461607"},{"key":"e_1_3_4_4_2","unstructured":"Evans J Richards JR Battisti AS. 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