{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:57:30Z","timestamp":1782939450760,"version":"3.54.5"},"reference-count":38,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    Allergic rhinitis (AR) has become a global health concern due to its increasing prevalence, significantly impacting the quality of life. Traditional treatment options often provide only temporary symptom relief and may cause adverse effects, leading to the exploration of alternative therapies. This study evaluates the effectiveness and safety of standardized\n                    <jats:italic toggle=\"yes\">Saururus chinensis<\/jats:italic>\n                    extract (LHF618) for alleviating symptoms of AR. Over a 4-week period, patients receiving LHF618 showed significant reductions in total nasal symptom scores, particularly for symptoms such as nasal itching, sneezing, and congestion, compared with the control group. Additionally, LHF618 led to a marked improvement in rhinitis control assessment test scores and a significant reduction in specific immunoglobulin E levels related to dust mite allergens. Importantly, no significant adverse effects were observed, indicating that LHF618 is a well-tolerated and safe option. These findings suggest LHF618 could be a promising natural alternative for managing AR, especially in cases related to dust mite allergies.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2025.k.0008","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T23:39:04Z","timestamp":1749080344000},"page":"802-811","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of\n                    <i>Saururus chinensis<\/i>\n                    Extract (LHF618) for Treating Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-1154","authenticated-orcid":false,"given":"Yoonhee","family":"Lee","sequence":"first","affiliation":[{"name":"Bio Technology R&amp;D Center, WiLab Co. Ltd., Seoul, South Korea."},{"name":"Department of Food and Nutrition, Sookmyung Women\u2019s University, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Bio Technology R&amp;D Center, WiLab Co. Ltd., Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Bio Technology R&amp;D Center, WiLab Co. Ltd., Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Bio Technology R&amp;D Center, WiLab Co. Ltd., Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Ryun","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbum","family":"Kwon","sequence":"additional","affiliation":[{"name":"Bio Technology R&amp;D Center, WiLab Co. Ltd., Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124612"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.050"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2019.01291"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.112472"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.12.012"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2020.04.001"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.16.1744"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.106150"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-020-00436-y"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.08.016"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114400"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.211"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b110670"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.08.009"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2005.8.190"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5349"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.10043"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105930"},{"key":"e_1_3_6_20_2","unstructured":"U.S. Department of Health and Human Services. Food and Drug Administration (CDER) CfDEaR. Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers. Rockville MD; 2005. Available from: https:\/\/www.fda.gov\/media\/72309\/download [Last accessed: April8 2022]."},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.4168\/aard.2017.5.4.205"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23219"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210017"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.022"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01344-4"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.7.3853"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-7-s1-s3"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071120"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248158"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-6749(05)80227-1"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.2635\/5\/eurrev_202206_29072"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf02977330"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050623"},{"issue":"3","key":"e_1_3_6_34_2","first-page":"47","article-title":"Role of quercetin (a natural herbal compound) in allergy and inflammation","volume":"20","author":"Shaik YB","year":"2006","unstructured":"Shaik YB, , Castellani ML, , Perrella A, et al. Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents, 2006; 20(3\u20134):47\u201352","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4195"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8693-0"},{"issue":"4","key":"e_1_3_6_37_2","first-page":"299","article-title":"The differences in serum quantitative specific IgE levels induced by dermatophagoides pteronyssinus, dermatophagoides farinae and blomia tropicalis sensitization in intermittent and persistent allergic asthma","volume":"49","author":"Susanto AJ","year":"2017","unstructured":"Susanto AJ, , Rengganis I, , Rumende CM, et al. The differences in serum quantitative specific IgE levels induced by dermatophagoides pteronyssinus, dermatophagoides farinae and blomia tropicalis sensitization in intermittent and persistent allergic asthma. Acta Med Indones, 2017; 49(4):299\u2013306","journal-title":"Acta Med Indones"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2016.8.4.329"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4361"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jmf.2025.k.0008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2025.k.0008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jmf.2025.k.0008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:32:42Z","timestamp":1777645962000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jmf.2025.k.0008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1089\/jmf.2025.k.0008"],"URL":"https:\/\/doi.org\/10.1089\/jmf.2025.k.0008","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]}}}