{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:34:54Z","timestamp":1778754894383,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2009,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      To report a case of fungal keratitis caused by\n                      <jats:italic toggle=\"yes\">Colletotrichum gloeosporioides<\/jats:italic>\n                      , which is a rare pathogen in humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>An 80-year-old woman developed fungal keratitis after having sustained a traumatic injury during field work. The patient was initially examined by slit-lamp biomicroscopy and the Heidelberg Retina Tomograph II-Rostock Cornea Module (HRT II-RCM). Corneal scrapings were collected and submitted for laboratory investigations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Many septate, hyphae-like interlocking and branching white lines were observed in the area of the infiltrate by HRT II-RCM. A tentative diagnosis of fungal keratitis was made, and the patient was treated with systemic and topical voriconazole and pimaricin ophthalmic ointment. The infectious focus resolved within 2 weeks, and there were no signs of a recurrence after 3 months of treatment with the antifungal agents. The culture of the corneal scraping grew\n                      <jats:italic toggle=\"yes\">C. gloeosporioides<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      HRT II-RCM was useful in detecting filamentous fungi in the cornea. The treatment with voriconazole and pimaricin was effective in the treatment of\n                      <jats:italic toggle=\"yes\">C. gloeosporioides<\/jats:italic>\n                      keratitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2009.0069","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T20:07:05Z","timestamp":1261512425000},"page":"563-566","source":"Crossref","is-referenced-by-count":20,"title":["<i>In Vivo<\/i>\n                    and\n                    <i>In Vitro<\/i>\n                    Investigations of Fungal Keratitis Caused by\n                    <i>Colletotrichum gloeosporioides<\/i>"],"prefix":"10.1177","volume":"25","author":[{"given":"Arisa","family":"Mitani","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ehime University Hospital, Shitsukawa, Toon-City, Ehime, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Regenerative Medicine, Ehime University School of Medicine, Ehime University Hospital, Shitsukawa, Toon-City, Ehime, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Uno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ehime University Hospital, Shitsukawa, Toon-City, Ehime, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Ehime University Hospital, Shitsukawa, Toon-City, Ehime, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ehime University Hospital, Shitsukawa, Toon-City, Ehime, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ehime University Hospital, Shitsukawa, Toon-City, Ehime, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ehime University Hospital, Shitsukawa, Toon-City, Ehime, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,12,22]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01576-3"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200401000-00002"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199705000-00019"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200111000-00027"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.10.3060-3065.1998"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.113691"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.07.033"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.11.078"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.262-268.2006"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.107243"}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jop.2009.0069","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2009.0069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2009.0069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:35:42Z","timestamp":1777646142000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jop.2009.0069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,1]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12,1]]}},"alternative-id":["10.1089\/jop.2009.0069"],"URL":"https:\/\/doi.org\/10.1089\/jop.2009.0069","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,1]]}}}