{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:09:51Z","timestamp":1784873391227,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2009,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report and evaluate the anatomic, clinical, and visual acuity response after intravitreal ranibizumab (IVR) injection in patients with cystoid macular edema (CME) due to retinitis pigmentosa (RP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study included 30 eyes of 30 patients with RP who had persistent CME at least 6 months despite medication with acetazolamide. Fifteen eyes of 15 eligible patients were treated with 0.5 mg IVR injection (treatment group). Fifteen eyes of 15 patients with the same characteristics who refused treatment were accepted as control group. The primary outcome of the study (morphologic restitution) was the complete or significant resolution of cystoid space on optic coherence tomography (OCT) without relapse or complication at 6 months. The serial changes in best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirteen eyes (86.6%) in the treatment group had significant resolution of CME at 6 months after single IVR injection. The difference between the 2 groups in BCVA was not statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). The baseline mean \u00b1 SD CFT for the treatment and control groups were 478 \u00b1 88 \u00b5m and 469 \u00b1 75 \u00b5m, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). At 6 months after treatment, the mean \u00b1 SD CFT of the treatment group improved to 272 \u00b1 65 \u00b5m whereas that in the control group was 480 \u00b1 92 \u00b5m (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This investigation indicated that IVR may provide a new therapeutic approach for the treatment of CME secondary to RP. No adverse event was found to be associated with the treatment. Continued experience with IVR in this population will help establish its longer-term efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2009.0089","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T20:07:05Z","timestamp":1261512425000},"page":"545-550","source":"Crossref","is-referenced-by-count":37,"title":["Intravitreal Ranibizumab in the Treatment of Cystoid Macular Edema Associated With Retinitis Pigmentosa"],"prefix":"10.1177","volume":"25","author":[{"given":"Ozgur","family":"Artunay","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Istanbul Bilim University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Yuzbasioglu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Bilim University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifat","family":"Rasier","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Bilim University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Sengul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Bilim University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Bahcecioglu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Bilim University, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,12,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.1999.0957"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(98)00046-0"},{"key":"e_1_3_2_4_2","first-page":"687","article-title":"Retinitis pigmentosa","volume":"101","author":"Hamel C.","year":"2006","unstructured":"Hamel C. 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