{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:47:53Z","timestamp":1777909673689,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T00:00:00Z","timestamp":1318809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the effect of 24-h peak intraocular pressure (IOP) on the progression of primary open-angle glaucoma (POAG) and the 24\u2009h time points that best predict peak pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective analysis of clinical data evaluating long-term glaucomatous progression in patients with POAG who were previously in a 24-h study of the authors (IOP readings at 2\/6\/10 A.M. and 2\/6\/10 PM); had \u22653 treated 10 A.M. (\u00b11\u2009h) IOP measurements over 5-years after an untreated 24-h baseline; and had a treated 24-h curve with a 10 A.M. IOP\u00b12\u2009mmHg within the 10 A.M. mean IOP over 5-years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We included 98 nonprogressed and 53 progressed patients with POAG (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =151). The mean 24-h peak IOP (mmHg) was 19.9\u00b12.7 for progressed and 18.3\u00b12.0 for nonprogressed patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Progressed patients also showed a higher mean 24-h IOP. Generally, patients with a mean or peak daytime (readings at 10 A.M., 2 and 6 P.M.) or 24-h peak IOP of \u226418 remained nonprogressed in 75%\u201378% of cases. Further, measuring IOP at night found a higher peak in only 20% of cases, which was \u22642 of the daytime peak in 98% of cases. A multivariate regression analysis showed only 24-h peak IOP as an independent risk factor for progression (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study suggests that daytime peak IOP may be clinically important in predicting long-term glaucomatous progression. Further, daytime peak IOP may assist, as much as daytime mean IOP and, in most cases, 24-h peak IOP, in helping to guide long-term treatment in POAG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2011.0081","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T11:28:54Z","timestamp":1318850934000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":68,"title":["Peak Intraocular Pressure and Glaucomatous Progression in Primary Open-Angle Glaucoma"],"prefix":"10.1177","volume":"28","author":[{"given":"Anastasios G.P.","family":"Konstas","sequence":"first","affiliation":[{"name":"Glaucoma Unit, 1st University","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Quaranta","sequence":"additional","affiliation":[{"name":"University of Brescia","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios G.","family":"Mikropoulos","sequence":"additional","affiliation":[{"name":"Glaucoma Unit, 1st University","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayssa B.","family":"Nasr","sequence":"additional","affiliation":[{"name":"Glaucoma Unit, 1st University","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Russo","sequence":"additional","affiliation":[{"name":"University of Brescia","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harris A.","family":"Jaffee","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette A.","family":"Stewart","sequence":"additional","affiliation":[{"name":"PRN Pharmaceutical Research Network"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Stewart","sequence":"additional","affiliation":[{"name":"PRN Pharmaceutical Research Network"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,10,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2006.22.26"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702995"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2008.0056"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702351"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067210801800517"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71282-6"},{"key":"e_1_3_2_9_2","first-page":"2566","article-title":"Effect of timolol, latanoprost, and dorzolamide on circadian IOP in glaucoma or ocular hypertension","volume":"41","author":"Orzalesi N.","year":"2000","unstructured":"Orzalesi N., , Rossetti L., , Invernizzi T., , Bottoli A., , Autelitano A. 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