{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:53:09Z","timestamp":1778777589828,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:00:00Z","timestamp":1322784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"Abstract<\/jats:title>\n \n Purpose:<\/jats:title>\n The aim of this study was to investigate the sensitization, pharmacokinetics, and absorption of FK506 after corneal transplantation.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n New Zealand albino rabbits were divided into normal and corneal transplantation groups. Each group was divided into 5 subgroups\u2014saline, blank matrix, high-dose, medium-dose, and low-dose, respectively. There were 10 rabbits in each subgroup. One drop (25\u2009\u03bcL) of FK506 was administered topically to both eyes of the rabbits 4 times daily for 30 days. Thirty days later, 5 rabbits of each subgroup were sacrificed after the administration of the last dose. Both eyes were enucleated; the left eye was used for pathologic examination and the right eye for the determination of FK506 distribution. The other 5 rabbits in each subgroup were sacrificed 14 days after the former 5 rabbits were sacrificed, and their eyes were enucleated for pathologic examination and tissue distribution determination as the former 5 rabbits in each subgroup (the second batch).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Fluorescein staining and local ocular reaction provided evidence that there were no significant differences between control and FK506-instilled eyes in the rabbit model at any of the tested doses. Histologic examination revealed no ocular abnormality in the rabbits instilled with any doses of FK506 eyedrop. The peak serum concentration (C\n max<\/jats:sub>\n ) of systemic absorption ranged from 4.31\u00b10.79\u2009ng\/mL to 14.89\u00b16.85\u2009ng\/mL.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Our study suggests that up to 0.1% FK506 administered 4 times a day (q.i.d.) topically is safe for the rabbit eye. However, further safety studies are required in view of systemic adverse effects.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/jop.2011.0108","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T10:16:09Z","timestamp":1322907369000},"page":"153-158","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Ocular Safety and Pharmacokinetics Study of FK506 Suspension Eye Drops After Corneal Transplantation"],"prefix":"10.1177","volume":"28","author":[{"given":"Jin","family":"Yuan","sequence":"first","affiliation":[{"name":"Zhongshan Ophthalmic Center at Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-jie","family":"Zhai","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology and Visual Sciences of Guangdong Province","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center at Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-you","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center at Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center at Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.40.1249"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00216-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11196-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199403270-00013"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V122368"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199306000-00023"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00226-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.24.11205"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.38.22602"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1947"},{"issue":"1","key":"e_1_3_2_12_2","first-page":"3156","article-title":"Suppression of corneal graft rejection in rabbits by a new immunosuppressive agent, FK-506","volume":"21","author":"Kobayashi C.","year":"1989","unstructured":"Kobayashi C., , Kanai A., , Nakajuima A. et al. Suppression of corneal graft rejection in rabbits by a new immunosuppressive agent, FK-506. Transplant Proc., 1989; 21,1 Pt 3:3156\u20133158.","journal-title":"Transplant Proc."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2008.0125"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.04.028"},{"key":"e_1_3_2_15_2","first-page":"100","article-title":"Interspecies comparison of the immunosuppressive efficacy and safety of FK506","volume":"22","author":"Thomson AW","year":"1990","unstructured":"Thomson AW. Interspecies comparison of the immunosuppressive efficacy and safety of FK506. Transplant Proc., 1990; 22:100\u2013105.","journal-title":"Transplant Proc."},{"key":"e_1_3_2_16_2","first-page":"2737","article-title":"Ocular absorption of topocally applied FK506 from liposomal and oil formulations in the rabbit eye","volume":"34","author":"Pleyer U.","year":"1993","unstructured":"Pleyer U., , Lutz S., , Juske W.J. et al. Ocular absorption of topocally applied FK506 from liposomal and oil formulations in the rabbit eye. Invest. Ophthalmol. Vis. Sci., 1993; 34:2737\u20132742.","journal-title":"Invest. Ophthalmol. Vis. 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