{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:48:04Z","timestamp":1777909684910,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T00:00:00Z","timestamp":1336089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the intraocular pressure (IOP)-lowering effect of 0.005% latanoprost used once every other day versus once daily in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Forty eyes of 20 patients with bilateral OHT or early POAG were enrolled in this prospective, randomized, crossover study. After a washout period of 1\u20134 weeks, each patient started latanoprost once daily in 1 randomly assigned eye and once every other day in the other eye. After 1 month, eyes were crossed over to the opposite dosing regimen for another month. IOP was measured at 9\n                      <jats:sc>am<\/jats:sc>\n                      , 4\n                      <jats:sc>pm<\/jats:sc>\n                      , and 9\n                      <jats:sc>pm<\/jats:sc>\n                      , both at baseline and on 2 consecutive days, at the end of the first and second months. The main outcome measure was IOP reduction on the second day at the end of the first and second months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean\u00b1standard deviation (SD) baseline IOPs (mmHg) in the right and left eye were 25.6\u00b12.6 and 25.5\u00b12.7 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.8), respectively. Mean\u00b1SD diurnal IOPs decreased (mmHg) by 8.6\u00b12.5 in the once-daily group versus 7.3\u00b12.3 in the every-other-day group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) at the end of the first month and 8.4\u00b12.5 versus 7.7\u00b12.5 at the end of the second month (both on day 2) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Once every-other-day administration of latanoprost significantly reduced the IOP although the IOP reduction was less pronounced 36\u201348\u2009h after drug application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2011.0167","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T17:54:57Z","timestamp":1336154097000},"page":"524-528","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Intraocular Pressure\u2013Lowering Effect of 0.005% Latanoprost with Two Different Dosing Regimens"],"prefix":"10.1177","volume":"28","author":[{"given":"Naveed","family":"Nilforushan","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Naghibi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siamak","family":"Shokrollahi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Soltan Sanjari","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouros","family":"Nouri-Mahdavi","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,5,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00098-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02305.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.01.042"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200320080-00005"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199400310-00012"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1998.0508"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.6.794"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713689609017628"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00328-4"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.01862.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790604.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00296-5"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00930-2"},{"key":"e_1_3_3_15_2","first-page":"297","article-title":"Intraocular pressure lowering effect of once daily versus once weekly instillation in the same normal individuals","volume":"53","author":"Darhad U.","year":"2008","unstructured":"Darhad U., , Nakamura M., , Fujioka M. et al. 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