{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:48:11Z","timestamp":1777909691628,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this article is to investigate clinical research on indications, posology, efficacy, and safety of epidermal growth factor (EGF) eye drops in the treatment of some human corneal disorders. Methods used include systematic search and selection of series of cases and clinical trials in Medline database up to January 2012, kappa index (\n                    <jats:italic toggle=\"yes\">K<\/jats:italic>\n                    ) to validate retrieval information, cumulative Mantel-Haenszel-stratified meta-analysis, 2\u00d72 contingency table of randomized EGF-vehicle-controlled treated groups, and statistical program SPSSv12. Our results indicate that EGF eye drops appear to be a very effective treatment of acute heterogeneous corneal diseases, without significant adverse effects, with a 86.8% clinical efficacy reported by authors, a 98% (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.05) probabilistic expected efficacy, and 51.3 (17.4\u2013148.7 confidence interval 95%;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.05) odds ratio EGF\/vehicle. However, clinical trials are scarce, with low sample sizes and serious inconsistencies in EGF posology. EGF eye drops (50\u20131,000\u2009ng, 2\u20133 times\/day) could be a useful treatment for promoting postoperative refractive surgery, reversing cases of keratopathy secondary to systematic EGF receptor inhibitors, diabetic keratopathy, and other corneal and conjunctival disorders.\n                  <\/jats:p>","DOI":"10.1089\/jop.2011.0236","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T13:10:42Z","timestamp":1335445842000},"page":"467-472","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Posology, Efficacy, and Safety of Epidermal Growth Factor Eye Drops in 305 Patients: Logistic Regression and Group-Wise Odds of Published Data"],"prefix":"10.1177","volume":"28","author":[{"given":"Jos\u00e9 Manuel","family":"Lou-Bonafonte","sequence":"first","affiliation":[{"name":"University of Zaragoza","place":["Spain"]},{"name":"Instituto de Salud Carlos III","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bonafonte-Marquez","sequence":"additional","affiliation":[{"name":"Hospital Divino Vall\u00e9s","place":["Spain"]},{"name":"Centro de Oftalmolog\u00eda Bonafonte","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Bonafonte-Royo","sequence":"additional","affiliation":[{"name":"Centro de Oftalmolog\u00eda Bonafonte","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro A.","family":"Mart\u00ednez-Carpio","sequence":"additional","affiliation":[{"name":"Centro de Oftalmolog\u00eda Bonafonte","place":["Spain"]},{"name":"Research Unit","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(90)90127-H"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-19910501-08"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050034"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(99)00048-0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00261-X"},{"key":"e_1_3_3_7_2","first-page":"992","article-title":"Impact of regenerated silk protein membrane of the cytokine expression of transfected human corneal epithelial cells","volume":"45","author":"Zhang X.F.","year":"2009","unstructured":"Zhang X.F., , Liu T.L., , Sheng W.H., , Yang J.C., , Miao J.C. Impact of regenerated silk protein membrane of the cytokine expression of transfected human corneal epithelial cells. Zhonghua Yan Ke Za Zhi., 45:992\u2013998. 2009.","journal-title":"Zhonghua Yan Ke Za Zhi."},{"key":"e_1_3_3_8_2","first-page":"1879","article-title":"Presence of epidermal growth factor in human tears","volume":"30","author":"Ohashi Y.","year":"1989","unstructured":"Ohashi Y., , Motokura M., , Kinoshita Y. et al. Presence of epidermal growth factor in human tears. Invest. Ophthalmol. Vis. Sci., 30:1879\u20131882. 1989.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02169794"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3875"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.19.3.201.5309"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1996.12.239"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0900"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.07.012"},{"key":"e_1_3_3_15_2","first-page":"9","article-title":"A study on effect of bFGF, EGF and NGF on growth of cultured human corneal endothelial cells","volume":"24","author":"Shao Y.","year":"2008","unstructured":"Shao Y., , Hu D., , Chen J. A study on effect of bFGF, EGF and NGF on growth of cultured human corneal endothelial cells. Yan Ke Xue Bao., 24:9\u201312. 2008.","journal-title":"Yan Ke Xue Bao."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.01.002"},{"key":"e_1_3_3_17_2","first-page":"1946","article-title":"Effects of human epidermal growth factor on endothelial wound healing of human corneas","volume":"33","author":"Hoppenreijs V.P.","year":"1992","unstructured":"Hoppenreijs V.P., , Pels E., , Vresen G.F., , Oosting J., , Treffers W.F. Effects of human epidermal growth factor on endothelial wound healing of human corneas. Invest. Ophthalmol. Vis. Sci., 33:1946\u20131957. 1992.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0904"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713689609007618"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.1150"},{"key":"e_1_3_3_21_2","first-page":"409","article-title":"Corneal wound healing after penetrating keratoplasty with EGF application. Experimental studies","volume":"101","author":"Szaflik J.","year":"1999","unstructured":"Szaflik J., , Fryczkowski A.W., , Liberek I. et al. Corneal wound healing after penetrating keratoplasty with EGF application. Experimental studies. Klin Oczna., 101:409\u2013416. 1999.","journal-title":"Klin Oczna."},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2001.64"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(92)90130-K"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(95)90773-S"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6964.1286"},{"key":"e_1_3_3_26_2","first-page":"595","article-title":"Strategies for health information retrieval","volume":"124","author":"Soualmia L.F.","year":"2006","unstructured":"Soualmia L.F., , Dahamna B., , Thirion B., , Darmoni S.J. Strategies for health information retrieval. Stud. Health. Tecnol. Inform., 124:595\u2013600. 2006.","journal-title":"Stud. Health. Tecnol. Inform."},{"key":"e_1_3_3_27_2","first-page":"579","article-title":"Efficacy and safety of intravitreal injection of bevacizumab in the treatment of neovascular glaucoma: systematic review","volume":"83","author":"Mart\u00ednez-Carpio P.A.","year":"2008","unstructured":"Mart\u00ednez-Carpio P.A., , Bonafonte-M\u00e1rquez E., , Heredia-Garc\u00eda C.D., , Bonafonte-Royo S. Efficacy and safety of intravitreal injection of bevacizumab in the treatment of neovascular glaucoma: systematic review. Arch. Soc. Esp. Ophthalmol., 83:579\u2013588. 2008.","journal-title":"Arch. Soc. Esp. Ophthalmol."},{"key":"e_1_3_3_28_2","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel J.","year":"1959","unstructured":"Mantel J., , Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer. Inst., 22:719\u2013748. 1959.","journal-title":"J. Natl. Cancer. Inst."},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2753.1997.00092.x"},{"key":"e_1_3_3_31_2","first-page":"515","article-title":"Observation, Sherlock Holmes, and evidence based medicine","volume":"14","author":"Osborn J.","year":"2002","unstructured":"Osborn J. Observation, Sherlock Holmes, and evidence based medicine. Med. Secoli., 14:515\u2013527. 2002.","journal-title":"Med. Secoli."},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00414564"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(84)90121-1"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000309941"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000310325"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199207000-00007"},{"key":"e_1_3_3_37_2","first-page":"443","article-title":"Local treatment by epidermal growth factor after epikeratoplasty. A double-blind clinical trial","volume":"15","author":"Ganem S.","year":"1992","unstructured":"Ganem S., , Mondon H., , De Felice G.P. Local treatment by epidermal growth factor after epikeratoplasty. A double-blind clinical trial. J. Fr. Ophtalmol., 15:443\u2013447. 1992.","journal-title":"J. Fr. Ophtalmol."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1159\/000310376"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1045517"},{"key":"e_1_3_3_40_2","first-page":"268","article-title":"Lacrimal secretion of human epidermal growth factor in perforating keratoplasty","volume":"5","author":"Sch\u00fcller S.","year":"1996","unstructured":"Sch\u00fcller S., , Knorr M., , Steuhl K.P., , Thiel H.J. Lacrimal secretion of human epidermal growth factor in perforating keratoplasty. Ger. J. Ophthalmol., 5:268\u2013274. 1996.","journal-title":"Ger. J. Ophthalmol."},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.5.391"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1159\/000310447"},{"key":"e_1_3_3_43_2","first-page":"176","article-title":"The basic and applied study on the epidermal growth factor","volume":"23","author":"Huang B.R.","year":"2001","unstructured":"Huang B.R., , Cai L.W., , Xiang X.Z. The basic and applied study on the epidermal growth factor. Zhongguo Yi Xue Ke Xue Yuan Xue Bao., 23:176\u2013180. 2001.","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao."},{"key":"e_1_3_3_44_2","first-page":"199","article-title":"Effect of recombinant epidermal growth factor on corneal epithelial cells after excision of pterygium","volume":"23","author":"Hong H.","year":"2001","unstructured":"Hong H., , Zhang W., , Liu P., , Zhu P. Effect of recombinant epidermal growth factor on corneal epithelial cells after excision of pterygium. Zhongguo Yi Xue Ke Xue Yuan Xue Bao., 23:199\u2013201. 2001.","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao."},{"key":"e_1_3_3_45_2","first-page":"437","article-title":"Effect of recombinant epidermal growth factor on ocular surface re-epithelization following amniotic membrane transplantation in patients with pterygium excision","volume":"22","author":"Li Z.","year":"2002","unstructured":"Li Z., , Lin Y.S., , Guo H., , Li D.M, , Zhang H.Y. Effect of recombinant epidermal growth factor on ocular surface re-epithelization following amniotic membrane transplantation in patients with pterygium excision. Di Yi Jun Yi Da Xue Xue Bao., 22:437\u2013438. 2002.","journal-title":"Di Yi Jun Yi Da Xue Xue Bao."},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318064584a"},{"key":"e_1_3_3_47_2","first-page":"269","article-title":"Topical application of EGF for the therapy of persisting corneal erosion under cetuximab treatment","volume":"105","author":"F\u00f6rster C.G.","year":"2008","unstructured":"F\u00f6rster C.G., , Cursiefen C., , Kruse F.E. Topical application of EGF for the therapy of persisting corneal erosion under cetuximab treatment. Ophthalmologe., 105:269\u2013273. 2008.","journal-title":"Ophthalmologe."},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318166f483"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31818fdbc6"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181922146"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7125.140"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2009.11.002"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2010.498398"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003470050241"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.1998.760511.x"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003470170130"},{"key":"e_1_3_3_57_2","first-page":"195","article-title":"Scanning electron microscopic study: the effect of balanced salt solution on rabbit corneal endothelium","volume":"4","author":"Bonafonte S.","year":"1986","unstructured":"Bonafonte S., , Aguirre Vila-Coro A. Scanning electron microscopic study: the effect of balanced salt solution on rabbit corneal endothelium. Cornea., 4:195\u2013201. 1986.","journal-title":"Cornea."},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-198802000-00007"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(03)00202-1"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.4.390"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.168849"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.117572"}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jop.2011.0236","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2011.0236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2011.0236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:37:37Z","timestamp":1777646257000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jop.2011.0236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,26]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10,1]]}},"alternative-id":["10.1089\/jop.2011.0236"],"URL":"https:\/\/doi.org\/10.1089\/jop.2011.0236","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,26]]}}}