{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:48:44Z","timestamp":1777909724794,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      To investigate the rate of secondary glaucoma after intravitreal dexamethasone 0.7\u2009mg (Ozurdex\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) implantation over a clinical treatment period of 1 year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective study of a series of 16 patients (9 males, 7 females; mean age 76 years) suffering from central- or branch retinal vein occlusion treated with dexamethasone 0.7\u2009mg were followed up for 12 months. Main outcome measures were intraocular pressure (IOP) determined with Goldmann applanation tonometry (GAT) and Pascal dynamic contour tonometry (DCT), as well as best-corrected visual acuity (BCVA) and central retinal thickness measured with optical coherence tomography (OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>BCVA (logMAR) improved in treated patients from mean 0.81 at baseline to a peak of 0.47 after 2 months but declined irrespective of reinjections to 0.87 at 12 months. Central retinal thickness measured with OCT initially decreased but increased again with recurring macular edema. 69% of patients treated with dexamethasone 0.7\u2009mg had an IOP increase of at least 5\u2009mmHg. In total, 50% of patients had an increase of \u226510\u2009mmHg during the studied period. The IOP increase in treated eyes was significant 1, 2, 3, and 8 months after dexamethasone 0.7\u2009mg implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Secondary glaucoma after intravitreal injection of dexamethasone 0.7\u2009mg might be underestimated in the GENEVA studies. The clinical safety profile reported here calls for thorough identification of suitable patients and frequent IOP control if dexamethasone 0.7\u2009mg (Ozurdex) is applied as a long-term treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2012.0253","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T10:20:15Z","timestamp":1363083615000},"page":"560-565","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Secondary Glaucoma After Intravitreal Dexamethasone 0.7\u2009mg Implant in Patients with Retinal Vein Occlusion: A One-Year Follow-Up"],"prefix":"10.1177","volume":"29","author":[{"given":"Linda M.","family":"Meyer","sequence":"first","affiliation":[{"name":"Herzog Carl-Theodor Eye Clinic","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl-Ludwig","family":"Sch\u00f6nfeld","sequence":"additional","affiliation":[{"name":"Herzog Carl-Theodor Eye Clinic","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.07.017"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140443012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680701851902"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.10"},{"key":"e_1_3_3_6_2","first-page":"2627","article-title":"Increased interleukin-6 in aqueous humour of neovascular glaucoma","volume":"40","author":"Chen K.H.","year":"1999","unstructured":"Chen K.H., , Wu C.C., , Roy S., , Lee S.M., , Liu J.H. 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